Norplant R Ⅰ和CLa 长期埋植者的细胞遗传学效应对比研究

doi:10.3969/j.issn.1004-616x.1999.01.007

癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (1): 19-021.doi: 10.3969/j.issn.1004-616x.1999.01.007

Norplant R Ⅰ和CLa 长期埋植者的细胞遗传学效应对比研究

尹娇杨1 　孙晓玲2 　刘权章3

1沈阳医学院生物学教研室　沈阳　　110031 　2 辽宁省计划生育科学研究院遗传优生研究室　沈阳　110031 　3哈尔滨医科大学生物学教研室　哈尔滨　150086

收稿日期:1998-06-28 修回日期:1998-09-25 出版日期:1999-01-30 发布日期:1999-01-30

CYTOGENETICS CAMPARISON STUDIES ON EFFECTS OF NORPLANTR Ⅰ AND CLA SUBDERMAL IMPLANT

Yin Jiaoyang1,Sun Xiaoling2,Liu Quanzhang3

1Biology Section , Shenyang Medical College, Shenyang 　110031, 2Section of Genetics and Eugenics, Liaoning Research Institute of Family Planning, Shenyang 　110031, 3Biology Section, Harbin Medical College,Harbin 　150086

Received:1998-06-28 Revised:1998-09-25 Online:1999-01-30 Published:1999-01-30

摘要/Abstract

摘要： 对长期皮下埋植NorplantR Ⅰ型和CLa 型避孕药剂的妇女和正常对照组的妇女的染色体畸变、姊妹染色单体互换及细胞微核等细胞遗传学指标进行了研究。结果提示:NorplantR Ⅰ型可增加其应用者体内细胞诱变性环境的存在,使其染色体畸变率和姊妹染色单体互换率显著性增加,且有统计学意义,故应引起对长期皮下埋植NorplantR Ⅰ型长效避孕皮埋药剂是否存在致突变作用问题的重视和进一步研究。CLa 型长效避孕皮下埋植药剂未发现有明显的致突变作用,从细胞遗传学角度上看是安全的。

关键词: NorplantR I型, CLa 型, 长期皮下埋植避孕, 细胞遗传学

Abstract: We analysed cytogenetics indexes from 29 women and 27 women who had been implanting NorplantR Ⅰand CLa as a long2term cont raceptive system , respectively and f rom 19 women as the cont rol group. The results suggested that NorplantR Ⅰmay be induce the existence of an increase mutagenic environment in cells of its impanters and significantly higher f requencies of chromosome aberration and sister chromatid exchange , the problems of NorplantR Ⅰsubdermal implant for long term cont raception should be attached importance to and that this kind of CLa could not be a clastogen or mutagen2carcinogen.

Key words: Norplant R Ⅰ, CLa, Long-term subdermal implant for cont raception, Cytogenetics

尹娇杨　孙晓玲　刘权章. Norplant R Ⅰ和CLa 长期埋植者的细胞遗传学效应对比研究[J]. 癌变·畸变·突变, 1999, 11(1): 19-021.

Yin Jiaoyang, Sun Xiaoling, Liu Quanzhang. CYTOGENETICS CAMPARISON STUDIES ON EFFECTS OF NORPLANTR Ⅰ AND CLA SUBDERMAL IMPLANT[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(1): 19-021.

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Norplant R Ⅰ和CLa 长期埋植者的细胞遗传学效应对比研究

CYTOGENETICS CAMPARISON STUDIES ON EFFECTS OF NORPLANTR Ⅰ AND CLA SUBDERMAL IMPLANT

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