用细胞转化实验检测S 江有机污染致癌危险性

doi:10.3969/j.issn.1004-616x.1999.04.011

癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (4): 194-198.doi: 10.3969/j.issn.1004-616x.1999.04.011

用细胞转化实验检测S 江有机污染致癌危险性

刘家仁1 　庞永王旬1 　张尤恩1 　范　春1 　王贤珍1 　朱振岗1 　E. J . Love2

1 哈尔滨医科大学公共卫生学院　哈尔滨　150001 　2 Department of Community Health Sciences , Faculty of Medicine , The University of Calgary. Canada

收稿日期:1998-12-12 修回日期:1999-04-06 出版日期:1999-07-30 发布日期:1999-07-30

EVALUATION ON CARCINOGENIC RISK FROM ORGANIC POLLUTION IN THE S RIVER BY CELL TRANSFORMATION

Liu J iaren1 , Pang Yongxun1 , Zhang youen1 , Wang Xianzhen1 , Fan Chun1 , Zhu Zhengang1 , E. J . Love2

1 Department of Envi ronmental Heal th of Harbin Medical University , Harbin 　150001 , 2Department of Com munity Heal th Sciences , Facul ty of Medicine , The University of Calgary . Canada

Received:1998-12-12 Revised:1999-04-06 Online:1999-07-30 Published:1999-07-30

摘要/Abstract

摘要： 用S 江冬夏两季的江水有机提取物分别做NIH3T3 细胞转化试验。结果表明:江水有机提取物各剂量组均能诱发该细胞出现典型的细胞转化灶,其细胞转化率呈现剂量—反应关系。转化细胞的恶性表现是生长失去接触性抑制并能在软琼脂内生长。进一步提示了S 江有机污染有潜在的致癌危险性。

关键词: 有机污染, NIH3T3 细胞转化, 致癌性

Abstract: NIH3T3 cell line was used for the study t ransformation induction by organic ext racts from water in the Sriver. The result indicated that the malignant t ransformed foci were induced by organic extract s mentioned above and the cellular transformation frequencies presented a dose-response relationship and determination of malignant cells disappeared in rest raining of contact and grew in culture of soft agar while cont rol cells did not .Thus , the present study demonst rates further that organic pollution f rom water in the S river has the potential risk of carcinogencity.

Key words: Organic pollution, NIH3T3 Cell t ransformation, Carcinogencity

刘家仁　庞永王旬　张尤恩　范　春　王贤珍　朱振岗　E. J . Love. 用细胞转化实验检测S 江有机污染致癌危险性[J]. 癌变·畸变·突变, 1999, 11(4): 194-198.

Liu J iaren , Pang Yongxun , Zhang youen , Wang Xianzhen , Fan Chun , Zhu Zhengang , E. J . Love. EVALUATION ON CARCINOGENIC RISK FROM ORGANIC POLLUTION IN THE S RIVER BY CELL TRANSFORMATION[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(4): 194-198.

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用细胞转化实验检测S 江有机污染致癌危险性

EVALUATION ON CARCINOGENIC RISK FROM ORGANIC POLLUTION IN THE S RIVER BY CELL TRANSFORMATION

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