COX-2在胃癌组织中的表达及与Hp感染的关系探讨

doi:10.3969/j.issn.1004-616x.2003.03.006

癌变·畸变·突变 ›› 2003, Vol. 15 ›› Issue (3): 147-149.doi: 10.3969/j.issn.1004-616x.2003.03.006

COX-2在胃癌组织中的表达及与Hp感染的关系探讨

杨　蕾1,高　歌2,,赵建军3,盛传伦2

1.吉林大学中日联谊医院镜检科；2.吉林大学中日联谊医院消化内科；3.吉林大学中日联谊医院呼吸内科，吉林　长春130031

收稿日期:2002-11-14 修回日期:2003-02-27 出版日期:2003-07-30 发布日期:2003-07-30
通讯作者: 杨　蕾

CORRELATION BETWEEN CYCLOOXYGENASE-2 PROTEIN IN GASTRIC CARCINOMA AND

YANG Lei1 , GAO Ge2, ZHAO Jian - jun3 , et al

1.Department of Endoscopy; 2.Department of Digestive;3.Department of Respiratory, China-Japan United Hospital of JiLin University; Changchun 130031, China

Received:2002-11-14 Revised:2003-02-27 Online:2003-07-30 Published:2003-07-30
Contact: YANG Lei

摘要/Abstract

摘要： 目的：研究环氧化酶-2(cyclooxygenase-2，COX-2)在胃癌组织中的表达及与幽门螺旋杆菌(Helicobacter pylori，Hp)感染的关系，为寻找有效的胃癌预防措施提供理论依据。方法：用免疫组织化学法检测35例胃癌、18例胃的不典型增生及15例慢性浅表性胃炎组织中COX-2蛋白表达；用快速尿素酶法检测上述组织的Hp感染情况。　结果:胃癌、胃的不典型增生及慢性浅表性胃炎组织COX-2表达的阳性率分别为85.71 ％、72.22 ％和6.67 ％。共有35例COX-2阳性的胃组织Hp感染阳性。　结论：COX-2可能参与胃癌的早期形成，Hp感染可能是其过度表达的机制之一。

关键词: 环氧化酶-2, 幽门螺旋杆菌, 胃肿瘤, 胃的不典型增生

Abstract: Purpose: To investigate cyclooxygenase - 2(COX - 2) protein expression in gastric carcinoma and its relationship with the helicobacter pylori(Hp) infection,supply rationale for chemoprevention of gastric carcinoma. Methods: 35 biopsy specimen from gastric carcinoma,18 from gastric dysplasia and 15 from patients with chronic gastritis were examined for COX-2 protein expression by immunohistochemistry ,and Hp infection condition by urease test, respectively. Results: Positive rates of COX - 2 expression in gastric carcinoma group,gastric dysplasia group and chronic gastritis group were 85.71 ％,72.22 ％ and 6.67 ％,respectively. 35 patients in COX - 2 positive cases were Hp positive. Conclusion: COX-2 protein overexpression may contribute to an early event of gastric cancer development and Hp infection may be one of the mechanisms of COX - 2 overexpression.

Key words: cyclooxygenase - 2, Helicobacter pylori, gastric carcinoma, gastric dysplasia

杨　蕾, 高　歌, 赵建军, 盛传伦. COX-2在胃癌组织中的表达及与Hp感染的关系探讨[J]. 癌变·畸变·突变, 2003, 15(3): 147-149.

YANG Lei , GAO Ge, ZHAO Jian - jun , et al. CORRELATION BETWEEN CYCLOOXYGENASE-2 PROTEIN IN GASTRIC CARCINOMA AND[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(3): 147-149.

[1]	黄正接，江龙，尤俊，曾岳岳，吴炳霖，陈百胜，冯庆钊，罗琪. 实时荧光定量PCR 检测胃癌SOX2的表达及其临床意义[J]. 癌变·畸变·突变, 2014, 26(2): 104-107.
[2]	蔡尔慧,蔡绍先,陈玮莹,高永鑫,徐小华,杜忠仁,陈梅兰,李克*. 食管癌中环氧化酶-2表达与临床病理特征相关关系的Meta分析[J]. , 2011, 23(5): 362-366.
[3]	蔡兆根/ 于东红/ 王　萍/ 周　蕾/ 冯振中. RASSF1基因在胃癌中的表达及其临床意义[J]. 癌变·畸变·突变, 2008, 20(4): 279-283.
[4]	冯振中, 徐锦程, 承泽农. 血管内皮生长因子_C和环氧合酶_2表达与口腔鳞癌淋巴结转移的关系[J]. 癌变·畸变·突变, 2008, 20(2): 103-106.
[5]	曾　超, 贺修胜, 罗　桥, 赵　帅, 邓　敏. 胃癌中RUNX3蛋白表达与胃癌关系的研究[J]. 癌变·畸变·突变, 2006, 18(6): 455-458.
[6]	马秀梅, 王玉芳, 耿丽萍, 左连富. 幽门螺旋杆菌感染胃黏膜COX-2和P-gp表达与胃癌发生[J]. 癌变·畸变·突变, 2006, 18(1): 50-053.
[7]	杜　芸, 王小玲, 王永军, 吴国祥, 杨会钗, 左连富. 流式细胞术测定COX-2,iNOS基因蛋白在食管癌上的表达及其与Bcl-2,PCNA的相关性[J]. 癌变·畸变·突变, 2005, 17(4): 224-226.
[8]	张红宇, 孙　强, 王亚东, 张维祥, 杨卫军, 张锦瑜. 野生型P53、P16基因联合抑制人胃癌细胞HGC27生长的实验研究[J]. 癌变·畸变·突变, 2004, 16(6): 344-346.

COX-2在胃癌组织中的表达及与Hp感染的关系探讨

CORRELATION BETWEEN CYCLOOXYGENASE-2 PROTEIN IN GASTRIC CARCINOMA AND

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价