小鼠子宫增重试验检测六种常用有机磷农药拟雌激素样活性

doi:10.3969/j.issn.1004-616x.2004.04.007

癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (4): 211-213.doi: 10.3969/j.issn.1004-616x.2004.04.007

小鼠子宫增重试验检测六种常用有机磷农药拟雌激素样活性

郑　光, 周志俊, 戴旭峰, 孙运光, 郑　捷, 唐　颖, 孙　毅

复旦大学公共卫生学院, 上海　200032

收稿日期:2004-01-12 修回日期:2004-03-22 出版日期:2004-07-30 发布日期:2004-07-30
通讯作者: 周志俊

Mice Uterotrophic Assay to Detect the Estrogenic Effects of Six Common Used Organophosphrus Pesticides

ZHENG Guang, ZHOU Zhi-jun, DAI Xu-feng, et al

School of Public Health, Fudan university ,Shanghai 200032,China

Received:2004-01-12 Revised:2004-03-22 Online:2004-07-30 Published:2004-07-30
Contact: ZHOU Zhi-jun

摘要/Abstract

摘要： 背景与目的: 观察常用六种有机磷农药对未成年小鼠子宫湿重和子宫内膜增生的影响。材料与方法: 对未成年小鼠分别腹腔注射不同剂量的有机磷农药(乐果19 mg/kg、乙酰甲胺磷47 mg/kg、马拉硫磷87 mg/kg、对氧磷0.056 mg/kg、对硫磷0.4 mg/kg、久效磷3.54 mg/kg)，连续给药3 d后剖杀小鼠，检查子宫湿重、子宫内膜上皮细胞高度和子宫内膜基质层厚度。结果: 六种有机磷农药对子宫湿重和子宫脏器系数均无影响，乐果和马拉硫磷能引起小鼠子宫内膜上皮细胞高度和基质层厚度的增加，与对照相比差异有显著性。结论: 乐果和马拉硫磷可能具有拟雌激素样活性,尚需进一步验证。

关键词: 有机磷农药, 子宫增重试验, 子宫内膜上皮, 子宫内膜基质层

Abstract: BACKGROUND AND AIM: To study the estrogenic effects of common used organophosphrus pesticides, by the observation of the height of endometrium epidemic cells and the height of endometrium stroma cells of immature mice uterus treated with rganophosphrus pesticides. MATERIAL AND METHODS: Six kinds of organophosphrus pesticides dimethoate 19 mg/kg, acephate 47 mg/kg, paraoxon 0.056 mg/kg, malation 87 mg/kg, parathion 0.4 mg/kg and moncrotophos 3.54 mg/kg were given intraperitoneal for 3 days consecutively to mice respectively. All mice were sacrificed after three days, then the uterus wet weight, the ratio of uterus to body weight , the height of endometrium epidemic cells and the height of endometrium stroma cells were measured. RESULTS: All these six organophosphrus pesticides couldn't proliferate the immature mice' uterus wet weight and the ratio of uterus to body weight, but dimethoate and malation could induce increment of the height of endometrium epidemic cells and the height of endometrium stroma cells,compared with the control group(P<0.05). CONCLUSION: Dimethoate and malation maybe have the potential estrogenicity.

Key words: organophosphrus pesticides, uterotrophic assay, uterus endometrium epidemic cells, uterus endometrium stroma cells

郑　光, 周志俊, 戴旭峰, 孙运光, 郑　捷, 唐　颖, 孙　毅. 小鼠子宫增重试验检测六种常用有机磷农药拟雌激素样活性[J]. 癌变·畸变·突变, 2004, 16(4): 211-213.

ZHENG Guang, ZHOU Zhi-jun, DAI Xu-feng, et al. Mice Uterotrophic Assay to Detect the Estrogenic Effects of Six Common Used Organophosphrus Pesticides[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2004, 16(4): 211-213.

小鼠子宫增重试验检测六种常用有机磷农药拟雌激素样活性

Mice Uterotrophic Assay to Detect the Estrogenic Effects of Six Common Used Organophosphrus Pesticides

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