关键词: 宫颈癌, 髂内动脉灌注化疗, 根治术

Abstract: BACKGROUND ＆ AIM： To explore the clinical therapeutic effect of intraoperative internal iliac arterial chemotherapy in the course of radical surgery of cervical cancer . MATERIAL AND METHODS： To retrospectively analyse the clinical data of 105 patients with cervical cancer, who received a radical surgery of cervical cancer and were also administered Cisplatin(DDP) via the internal iliac artery during the operation(DDP group).A nonrandomized control group of 50 patients who were not administered DDP intraoperatively was used for comparison (control group). Their therapeutic effect in the near future, recurrence of postoperation and the result of follow-up (including the survival rate and recurrence rate) were analyzed and compared. RESULTS： The recurrence rate of DDP group was 4.81 ％ and 5 cases recurred diversion (3 cases pelvic cavity diversion, 2 cases distant diversion) within 3 years｀ follow-up and the recurrence rate of control group was 18.00 ％，and 8 cases recurred diversion(7 cases pelvic cavity diversion, 1 cases distant diversion) within 3 years' follow-up . The recurrence rate of control group was higher than that of the DDP group (P=0.027).The two years' survival rate in DDP group was 95.035 4 ％ and in control group was 83.623 7 ％ , respectively (P=0.047). The four years' survival rate was 95.035 4 ％ in DDP group and 79.483 3 ％ in control group(P=0.012). CONCLUSION： Intraoperative bilateral internal iliac arterial infusion chemotherapy in the course of radical surgery of cervical cancer can lower the recurrence rate the and effectively raise the survival rate.

Key words: cervical cancer, internal iliac arterial infusion chemotherapy, radical surgery