东北某市大气颗粒物质和多环芳烃类化合物的浓度及其致突变性

doi:10.3969/j.issn.1004-616x.2007.02.018

癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (2): 143-146.doi: 10.3969/j.issn.1004-616x.2007.02.018

东北某市大气颗粒物质和多环芳烃类化合物的浓度及其致突变性

朴丰源段志文张玉敏崔金山孙鲜策杨　光山内彻

1. 大连医科大学卫生学教研室，辽宁　大连 116027； 2. 沈阳医学院卫生毒理教研室，辽宁　沈阳　110034；3. 日本国立三重大学医学部，日本三重县　津市　514－8507

收稿日期:2006-04-17 修回日期:2006-11-13 出版日期:2007-03-30 发布日期:2007-03-30
通讯作者: 朴丰源

Concentrations and Mutagenic Activities of Ambient Particulate Matter and Polycyclic Aromatic Hydrocarbons

PIAO Feng-yuan1, DUAN Zhi-wen2, ZHANG Yu-min2, CUI Jin-shan2, SUN Xian-ce1, YANG Guang1, YAMAUCHI Toru3,

1.Department of Hygiene, Dalian Medical University, Dalian 116027, Liaoning, China; 2. Department of Hygiene Toxicology, Faculty of Preventive Medicine, Shenyang Medical College, Shenyang 110034, Liaoning, China; 3. Department of Public Health, Graduate School of Medicine, Mie University, Tsu 514－8507, Mie Prefecture, Japan

Received:2006-04-17 Revised:2006-11-13 Online:2007-03-30 Published:2007-03-30
Contact: PIAO Feng-yuan

摘要/Abstract

摘要： 背景与目的：调查东北某工业城市大气颗粒物质和多环芳烃类化合物的浓度以及它们的致突变活性。材料与方法：用大流量粉尘采样器采样，带有荧光检测仪的高压液相色谱仪(HPLC)检测总的多环芳香烃类化合物(PAHs)以及其中的苯并(a)芘 [B(a)P]的浓度。以Ames沙门氏菌致突变活性检测样品的致突变性。结果：工业区和交通干道大气中颗粒物质浓度高于居住区或郊区，工业区大气中颗粒物质中多环芳香烃化合物和苯并(a)芘的浓度高于郊区和交通干道(P<0.05或P<0.01)。工业区大气颗粒物质和有机提取物致沙门氏菌TA98和TA100回复突变率高于其他各区采样点(P<0.05或P<0.01)。结论：工业区大气中颗粒物质和多环芳香烃类化合物浓度较高，并具有很高的间接致突变活性和较弱的直接致突变活性。

关键词: 大气污染, 颗粒物质, 多环芳烃化合物, 致突变活性, Ames 试验

Abstract: BACKGROUND ＆ AIM: To investigate concentrations and mutagenic activities of ambient particulate matter (PM) and polycyclic aromatic hydrocarbons(PAHs) in an industrial area of northeastern China. MATERIALS AND METHODS: The concentrations of PM, PAHs and benzo(a)pyrene [B(a)P] were determined by high liquid chromatography (HPLC) and mutagenicity of the samples were examined by the Ames Salmonella mutagenic assay over two years from September 2000 to August 2002 in a northeast industrial city of China. RESULTS: Concentrations of PM, PAHs and BaA were significantly higher in the industrial area than those in the other sampling area(P<0.05 or P<0.01). Mutagenic activities of PM and its extracted organic matters(EOM) were significantly higher in the industrial area than those in the other sampling area(P<0.05 or P<0.01). CONCLUSION: Concentrations of PM and PAHs were high in the industrial area, and there were strong indirect mutagenic activities.

Key words: air pollution, particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), mutagenic activity, Ames test

中图分类号:

R994.6

朴丰源段志文张玉敏崔金山孙鲜策杨　光山内彻. 东北某市大气颗粒物质和多环芳烃类化合物的浓度及其致突变性[J]. 癌变·畸变·突变, 2007, 19(2): 143-146.

PIAO Feng-yuan, DUAN Zhi-wen, ZHANG Yu-min, CUI Jin-shan, SUN Xian-ce, YANG Guang, YAMAUCHI Toru, . Concentrations and Mutagenic Activities of Ambient Particulate Matter and Polycyclic Aromatic Hydrocarbons[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(2): 143-146.

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东北某市大气颗粒物质和多环芳烃类化合物的浓度及其致突变性

Concentrations and Mutagenic Activities of Ambient Particulate Matter and Polycyclic Aromatic Hydrocarbons

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