细胞外基质金属蛋白酶诱导因子及金属蛋白酶_9在乳腺癌中的表达及其意义

doi:10.3969/j.issn.1004-616x.2007.04.010

癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (4): 298-301.doi: 10.3969/j.issn.1004-616x.2007.04.010

细胞外基质金属蛋白酶诱导因子及金属蛋白酶_9在乳腺癌中的表达及其意义

梁运霞陈茂怀黄　博吴贤英

汕头大学医学院病理学教研室，广东　汕头

收稿日期:2007-04-13 修回日期:2007-05-08 出版日期:2007-07-30 发布日期:2007-07-30

The Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase_9 Expression in Breast Carcinoma

LIANG Yun_xia,CHEN Mao_huai,HUANG Bo,WU Xian_ying

Department of Pathology, Shantou Universit Medical College, Shantou

Received:2007-04-13 Revised:2007-05-08 Online:2007-07-30 Published:2007-07-30

摘要/Abstract

摘要： 背景与目的：研究细胞外基质金属蛋白酶诱导因子(EMMPRIN)和基质金属蛋白酶_9(MMP_9)的表达与乳腺癌发生和转移之间的关系。材料与方法：免疫组化法检测21例乳腺增生、10例导管内癌及68例浸润性导管癌中EMMPRIN和MMP_9的表达情况。结果： ①EMMPRIN在乳腺增生、导管内癌、浸润性导管癌表达阳性率分别为4.76％(1/21)、40.00％(4/10)、73.53％(50/68),3组之间的阳性率差异均有统计学意义(P<0.05)。②MMP_9在增生乳腺、导管内癌、浸润性导管癌的表达阳性率分别为 0.00％(0/21)、30.00％(3/10)、69.12％(47/68)，3组之间的阳性率差异亦均有统计学意义(P<0.05)。③乳腺癌组织内的EMMPRIN与MMP_9的表达成正相关(rS=0.676，P<0.01),而且EMMPRIN和MMP_9的过度表达与腋窝淋巴结转移及淋巴结转移数目呈正相关(P<0.01)。结论： EMMPRIN和MMP_9的过度表达可能在乳腺癌的发生发展过程中起重要作用，是促进乳腺癌发生、浸润、转移的重要因素，可作为评估乳腺癌浸润转移的重要生物学指标。

关键词: 乳腺癌, 转移, 细胞外基质金属蛋白酶诱导因子, 基质金属蛋白酶, 免疫组化

Abstract: BACKGROUND＆AIM: To study the correlation between the expression of extracellular matrix metalloproteinase inducer(EMMPRIN)and matrix metalloproteinase_9(MMP_9) and the development and metastasis of breast carcinoma. MATERIALS AND METHODS: The expressions of EMMPRIN and MMP_9 were evaluated by immunohistochemical staining in 21 cases of breast hyperplasia, 10 cases of intraductal carcinoma and 68 cases of invasive breast ductal carcinoma. RESULTS: ①The positive rates of EMMPRIN expression in hyperplasia, intraductal carcinoma and invasive breast carcinoma were 4.76％ (1/21), 40.00％ (4/10) and 73.53％ (50/68), respectively. Significant difference was found among three groups (P<0.05); ②The positive rates of MMP_9 expression in hyperplasia, intraductal carcinoma and invasive breast carcinoma were 0.00％ (0/21), 30.00％ (3/10) and 69.12％ (47/68), respectively. Significant difference was found among three groups too (P<0.05); ③ The expression of EMMRIN significantly correlated with the expression of MMP_9 in breast ductal carcinoma (rs=0.676,P<0.01). Axillary lymph node metastasis and the number of metastatic node were related to the expression of EMMPRIN and MMP_9 in breast ductal carcinoma(P<0.05). CONCLUSION: The over_expression of EMMPRIN and MMP_9 may play important roles in the development of breast carcinoma.They were found to be important factors that promoted the invasion and metastasis of breast carcinoma.EMMPRIN and MMP_9 could be important markers for evaluating invasion and metastasis of breast carcinoma.

Key words: breast carcinoma, metastasis, extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase_9 (MMP_9), immunohistochemistry

梁运霞陈茂怀黄　博吴贤英. 细胞外基质金属蛋白酶诱导因子及金属蛋白酶_9在乳腺癌中的表达及其意义[J]. 癌变·畸变·突变, 2007, 19(4): 298-301.

LIANG Yun_xia, CHEN Mao_huai, HUANG Bo, WU Xian_ying. The Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase_9 Expression in Breast Carcinoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(4): 298-301.

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细胞外基质金属蛋白酶诱导因子及金属蛋白酶_9在乳腺癌中的表达及其意义

The Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase_9 Expression in Breast Carcinoma

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