癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (3): 214-217.doi: 10.3969/j.issn.1004-616x.2010.03.013

• 论著 • 上一篇    下一篇

新疆地区甲状腺癌组织中ESR1基因表达及其临床意义的探讨

杨曦1;阿仙姑•哈斯木2;韶峰2;武爽1;阿布力孜•阿布杜拉3;夏米西努尔•伊力克1   

  1. 1. 新疆医科大学基础医学院生物教研室，新疆 乌鲁木齐 830011； 2. 新疆医科大学基础医学院病理教研室，新疆 乌鲁木齐 830011； 3. 新疆医科大学基础医学院科研中心，新疆 乌鲁木齐 830011
  • 收稿日期:2009-11-12 修回日期:2010-03-19 出版日期:2010-05-30 发布日期:2010-05-30
  • 通讯作者: 夏米西努尔•伊力克

Expression and significance of ESR1 in thyroid tumor tissues in Xinjiang

YANG Xi1;Ayshamgul.Hasim2;SHAO Feng2;WU Shuang1;Abulizi.Abudula3;Xiamixinuer.Yilike1   

  1. (1. Biology Department, Pre-clinical College of Xinjiang Medical University, Urumqi 830011; 2. Pathology Department, Pre-clinical College of Xinjiang Medical University, Urumqi 830011;3. Molecular Biology Laboratory, Pre-clinical College of Xinjiang Medical University, Urumqi 830011, Xinjiang, China
  • Received:2009-11-12 Revised:2010-03-19 Online:2010-05-30 Published:2010-05-30
  • Contact: Xiamixinuer.Yilike

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摘要： 目的： 研究雌激素受体(estrogen receptor alpha， ESR1)在新疆地区甲状腺癌组织中的表达，探讨其在临床中的意义。 方法： 用免疫组织化学SP法检测64 例甲状腺癌、21例甲状腺良性腺瘤、13例桥本氏甲状腺炎、6例结节性甲状腺肿和6例癌旁正常组织中ESR1基因表达，结合临床病理因素进行分析。 结果： ESR1在甲状腺癌组织中的阳性表达显著高于甲状腺腺瘤、桥本氏甲状腺炎、结节性甲状腺肿和癌旁正常组织(P<0.01)；甲状腺癌组织学类型、临床分期、淋巴结转移及预后与ESR1蛋白表达相关(P均<0.05)。 结论： ESR1可能在甲状腺癌的发生、发展过程中起到了重要作用，故阻断其作用环节可能为治疗甲状腺癌提供新策略。

关键词: 甲状腺肿瘤, 雌激素受体, 免疫组织化学

Abstract: OBJECTIVE: To investigate the expression of estrogen receptor alpha(ESR1) in thyroid cancer tissues and explore its clinical value. METHODS: The paraffin-embedded tissue sections of 64 thyroid cancer patients, 21 cases of thyroid adenoma, 13 cases of Hashimoto's thyroiditis, 6 cases of nodular goiter and 6 cases from the peri-tumor tissue were immunohistochemically examined for the expression of ESR1. The association between ESR1 expression and clinico- pathological parameters were analyzed. RESULTS: The positive rate of ESR1 in thyroid cancer tissues was significantly higher than those in thyroid adenoma, Hashimoto's thyroiditis, nodular goiter and peritumor tissues(P<0.01). The positive expression of ESR1 correlated significantly with tissue stage, clinical stage , lymph node metastasis and prognosis(P<0.05). CONCLUSION: ESR1 could play an important role in the occurrence and development of differentiated thyroid cancer, so to prevent the function of ESR1 may provide a new strategey to cure the thyroid cancer.

Key words: thyroid carcinoma, ESR1, immunohistology

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