东莨菪亭和橙皮素联用的镇痛效果定量分析

doi:10.3969/j.issn.1004-616x.2010.03.017

癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (3): 230-232.doi: 10.3969/j.issn.1004-616x.2010.03.017

东莨菪亭和橙皮素联用的镇痛效果定量分析

陈一村;蔡聪艺;冀宾;高分飞;张艳美;黄展勤;白雪婷;石刚刚

汕头大学医学院药理学教研室, 广东汕头 515041

收稿日期:2009-12-29 修回日期:2010-03-01 出版日期:2010-05-30 发布日期:2010-05-30
通讯作者: 石刚刚

Combination of scopoletin and hesperetin from Ipomoea Stolonifera using uniform design experimentation

CHEN Yi-cun;CAI Cong-yi;JI Bin;GAO Fen-fei;ZHANG Yan-mei;HUANG Zhan-qin;BAI Xue-ting;SHI Gang-gang

Department of Pharmacology, Medical College, Shantou University, Shantou 515041, Guangdong, China

Received:2009-12-29 Revised:2010-03-01 Online:2010-05-30 Published:2010-05-30
Contact: SHI Gang-gang

摘要/Abstract

摘要： 目的：应用均匀设计法，定量分析海滩牵牛中东莨菪亭和橙皮素联用对冰醋酸所致小鼠扭体实验的镇痛效果。方法：设置 5 个水平的东莨菪亭(S)和橙皮素(H)联用比例和剂量，采用冰醋酸致小鼠扭体模型,观察不同组合的镇痛效果，综合数理分析结果, 确定最优配方。结果：联合使用橙皮素194.5 mg/ kg和东莨菪亭15.36 mg/ kg 对冰醋酸所致小鼠扭体实验可达到最佳的抑制作用。最佳剂量范围， H：175～215 mg/kg；S:14～17 mg/kg。结论：本实验采用均匀设计法确定了海滩牵牛中东莨菪亭和橙皮素联用对冰醋酸所致小鼠扭体实验的镇痛效果的最佳配比。均匀设计法可用于多药物联用的定量分析,但有一定的局限, 其结果需经实验确证。

关键词: 海滩牵牛, 东莨菪亭, 橙皮素, 均匀设计法

Abstract: OBJECTIVE:To analyze quantitatively the analgesic effect of scopoletin and hesperetin from Ipomoea Stolonifera in combination using the method of uniform design. METHODS: According to the uniform design method, 5 different doses at 5 different proportions were administered (intra-gastric) to observe the analgesic effect to mice by writhing test. The optimal doses and proportions in combination were obtained from experimental data, by mathematical analysis and professional knowledge. RESULTS: The combination of hesperetin at 194.5 mg/kg and scopoletin at 15.36 mg/kg was appropriate. CONCLUSION: The uniform design method could be effectively applied to analyze the multidrug effects under some limited conditions, but the results must be verified by further experiment.

Key words: Ipomoea Stolonifera, hesperetin, scopoletin, uniform design experimentation

中图分类号:

R917

陈一村, 蔡聪艺, 冀宾, 高分飞, 张艳美, 黄展勤, 白雪婷, 石刚刚. 东莨菪亭和橙皮素联用的镇痛效果定量分析[J]. 癌变·畸变·突变, 2010, 22(3): 230-232.

CHEN Yi-cun, CAI Cong-yi, JI Bin, GAO Fen-fei, ZHANG Yan-mei, HUANG Zhan-qin, BAI Xue-ting, SHI Gang-gang. Combination of scopoletin and hesperetin from Ipomoea Stolonifera using uniform design experimentation[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(3): 230-232.

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[2]	郑付春;蔡聪艺;白雪婷;陈一村. 海滩牵牛微量元素水平及形态分析[J]. , 2012, 24(4): 286-289.

东莨菪亭和橙皮素联用的镇痛效果定量分析

Combination of scopoletin and hesperetin from Ipomoea Stolonifera using uniform design experimentation

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