癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (4): 279-282.doi: 10.3969/j.issn.1004-616x.2010.04.007

• 论著 • 上一篇    下一篇

微小染色体维持蛋白4在胃癌中的表达及与幽门螺杆菌感染的关系

荣芳1;王勇2;王满贵2;侯恒1;李丽芬1   

  1. 1. 大同大学医学院内科教研室，山西 大同 037008； 2. 大同市第五人民医院，山西 大同 037006
  • 收稿日期:2010-01-15 修回日期:2010-03-26 出版日期:2010-07-30 发布日期:2010-07-30
  • 通讯作者: 荣芳

The expression of minichromo- some maintenance proteins 4 in gastric cancer and correlation with H.pylori infection

RONG Fang1;WANG Yong2;WANG Man-gui2;HOU Heng1;LI Li-fen1   

  1. 1. Department of Medicine, Medical College, Datong University in Shanxi, Datong 037008; 2.Department of Pathology,The Fifth People's Hospital of Datong, Datong 037006, Shanxi, China
  • Received:2010-01-15 Revised:2010-03-26 Online:2010-07-30 Published:2010-07-30
  • Contact: RONG Fang

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摘要： 目的： 探讨微小染色体维持蛋白4(minichromosome maintenance proteins 4, MCMp4)在胃癌和癌前病变组织中的表达及与幽门螺杆菌(helicobacter pylori, Hp)感染的关系。 方法： 选取经病理证实的慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌4种不同胃黏膜病变的标本共140例，用免疫组织化学法检测标本中MCMp4的表达及幽门螺杆菌感染情况，分析MCMp4的表达与幽门螺杆菌感染的关系。 结果： 以慢性浅表性胃炎、胃溃疡、慢性萎缩性胃炎和胃癌为序，4种病变中MCMp4的表达率和Hp的感染率呈逐渐增加的趋势。在胃癌中Hp感染组MCMp4的表达率高于非感染组(P<0.05)，MCMp4的阳性表达率与Hp感染率之间呈正相关(r=0.457, P<0.05)。 结论： MCMp4表达和Hp的感染与胃癌的发生密切相关，检测这些指标可为胃癌诊断、预后判断和指导治疗提供参考。

关键词: 微小染色体维持蛋白4, 幽门螺杆菌, 免疫组织化学

Abstract: OBJECTIVE: To investigate the expression of minichromosome maintenance proteins 4 (MCMp4) in gastric cancer and precancerous condition and its correlation with helicobacter pylori (Hp) infection. METHODS: The expression of MCMp4 and the infection of Helicobacter pylori were studied by immunohistochemical methods in 140 gastric specimens including 25 chronic superficial gastritis(CSG), 30 gastric ulcer (GU), 35 chronic atrophic gastritis (CAG) and 50 gastric cancers (GC). RESULTS: In CSG,GU,CAG and GC, the expressions of MCMp4 and Hp were increased. The expression of MCMp4 in Hp positive group was significantly higher than that in negative group. The expression of MCMp4 was positively correlated with infection of Hp(r=0.457, P<0.05). CONCLUSION: MCMp4 and Hp may play important roles in carcinogenesis and progression of gastric cancer. The evaluation of MCMp4 and Hp could provide theoretical basis for diagnosing, evaluating prognosis and guiding treatment of gastric cancer.

Key words: minichromosome maintenance proteins 4, helicobacter pylori, immunohistochemistry

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