hCHK2基因tagSNPs位点及单体型与新疆哈、汉族食管癌关系的研究

doi:10.3969/j.issn.1004-616x.2010.04.009

癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (4): 287-291.doi: 10.3969/j.issn.1004-616x.2010.04.009

hCHK2基因tagSNPs位点及单体型与新疆哈、汉族食管癌关系的研究

尹东1;陈艳2;6;张慧霞2;王洪疆1;阿合力1;邓彦超3;6;马彦清4;居来提5

1. 新疆医科大学附属肿瘤医院，乌鲁木齐 830011; 2. 新疆医科大学公共卫生学院，乌鲁木齐 830011; 3. 新疆医科大学第一附属医院，乌鲁木齐 830011; 4.新疆伊犁州友谊医院，伊宁 835000; 5. 新疆伊犁州新华医院，伊宁 835000; 6.新疆食管癌研究所，乌鲁木齐 830011

收稿日期:2010-02-23 修回日期:2010-03-23 出版日期:2010-07-30 发布日期:2010-07-30
通讯作者: 陈艳

Study on relationship between tagSNPs and haplotype of hCHK2 gene and esophageal cancer in Kazakh and Han nationality in Xinjiang

Yin Dong1;Chen Yan2;6;Zhang Hui-xia2;Wang Hong-jiang1;Aheli1;Deng Yan-chao3;6;Ma Yan-qing4;Julaiti5

1.The Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011; 2.Department of Toxicology, Public Health College,Xinjiang Medical University, Urumqi 830011; 3.The First Hospital Affiliated to Xinjiang Medical University,Urumqi 830011; 4.Friendship Hospital of Xinjiang Yili, Yining 835000;5.Xinhua Hospital of Xinjiang Yili, Yining 835000; 6.Xinjiang Institute for Esophageal Cancer Research,Urumqi 830011,China

Received:2010-02-23 Revised:2010-03-23 Online:2010-07-30 Published:2010-07-30
Contact: Chen Yan

摘要/Abstract

摘要： 目的：探讨新疆哈萨克族、汉族食管癌患者hCHK2 基因rs2278022、rs2602431和rs2970077 3个tagSNPs位点及其单体型与食管癌易感性的关系。方法：以聚合酶链式反应-连接酶检测反应(PCR-LDR)技术，分析239例食管癌患者(其中哈族132例，汉族107例)和作为对照的513例非食管癌患者(其中哈族309例，汉族204例)hCHK2基因rs2278022、rs2602431和rs2970077 3个tagSNPs位点基因型的分布；利用SHEsis软件分析其构成的单体型在病例组和对照组中的分布频率，比较基因型和单体型在病例组和对照组间的分布差异。结果：在哈族和汉族人群中，hCHK2基因rs2278022、rs2602431和rs2970077位点基因型和等位基因的频率分布在病例组和对照组间的差异无统计学意义(P均>0.05)，其3个tagSNPs位点及其单体型，在哈族和汉族的病例组与对照组中的频率分布的差异均无统计学意义(P均>0.05)。结论： hCHK2基因rs2278022、rs2602431和rs2970077等3个tagSNPs位点及其单体型与哈萨克族和汉族食管癌易感性无关。

关键词: hCHK2基因, 单核苷酸多态性, 单体型, 食管癌, 哈萨克族

Abstract: OBJECTIVE: To determine the association of hCHK2 rs2278022, rs2602431, and rs2970077 polymorphism and haplotypes with the susceptibility of esophageal cancer in Kazakh and Han nationality in Xinjiang Uygur Autonomous Region. METHODS: A molecular epidemiology method was carried out of 239 cases of esophageal cancer(132 Kazakh nationality, 107 Han nationality)and 513 controls(309 Kazakh nationality, 204 Han nationality)in Xinjiang area. The polymorphism of hCHK2 gene at rs2278022, rs2602431 and rs2970077 position was analyzed by polymerase chain reaction-ligase detection reaction (PCR-LDR) methods. Haplotypes were estimated by the SHEsis software. The haplotype distribution statistical differences of the genotype and haplotype frequencies between the case group and the control group were estimated. RESULTS: No significant difference was observed in the frequency of hCHK2 gene at rs2278022, rs2602431 and rs2970077 position genotypes and allele genes between the cases and controls in Kazakh and Han nationality(P>0.05). In Kazakh and Han nationality, the distribution of haplotypes was not significantly different between esophageal cancer cases and controls(P>0.05); CONCLUSION: The polymorphism of hCHK2 gene at rs2278022, rs2602431 and rs2970077 position and haplotypes are unlikely to be associated with the susceptibility to esophageal cancer in Kazakh and Han nationality.

Key words: hCHK2 gene, single nucleotide polymorphism, haplotype, esophageal cancer, Kazakh nationality

中图分类号:

R735.1

尹东, 陈艳, 张慧霞, 王洪疆, 阿合力, 邓彦超, 马彦清, 居来提. hCHK2基因tagSNPs位点及单体型与新疆哈、汉族食管癌关系的研究[J]. 癌变·畸变·突变, 2010, 22(4): 287-291.

Yin Dong, Chen Yan, Zhang Hui-xia, Wang Hong-jiang, Aheli, Deng Yan-chao, Ma Yan-qing, Julaiti. Study on relationship between tagSNPs and haplotype of hCHK2 gene and esophageal cancer in Kazakh and Han nationality in Xinjiang[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(4): 287-291.

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hCHK2基因tagSNPs位点及单体型与新疆哈、汉族食管癌关系的研究

Study on relationship between tagSNPs and haplotype of hCHK2 gene and esophageal cancer in Kazakh and Han nationality in Xinjiang

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