T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系

doi:10.3969/j.issn.1004-616x.2010.06.012

癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (6): 458-461.doi: 10.3969/j.issn.1004-616x.2010.06.012

T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系

王素芬,黄卡特,陈　霖,杨开颜

温州医学院附属第一医院病理科，浙江温州 325000

收稿日期:2009-11-30 修回日期:2010-06-28 出版日期:2010-11-30 发布日期:2010-11-30
通讯作者: 杨开颜

Expression of MUM1 protein in T_cell lymphoma and its relationship with cell proliferation

WANG Su-fen， HUANG Ka-te， CHEN Lin， YANG Kai-yan

he Pathology Department of Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000，Zhejiang， China

Received:2009-11-30 Revised:2010-06-28 Online:2010-11-30 Published:2010-11-30
Contact: YANG Kai-yan

摘要/Abstract

摘要： 目的：探讨T细胞淋巴瘤中MUM1蛋白的表达及其与肿瘤细胞增殖的关系。方法：收集诊断及分型均明确的T细胞淋巴瘤患者的石蜡包埋组织58例，其中T淋巴母细胞性淋巴瘤/白血病(precursor T lymphoblastic lymphoma/leukemia, T_LBL/L)9例、间变性大细胞淋巴瘤(anaplastic large T cell lymphoma, ALCL)12例和外周T细胞性淋巴瘤(peripheral T cell lymphoma，PTL)37例。另选2例反应性增生性淋巴结炎组织作对照。应用免疫组织化学法检测各组织中MUM1蛋白、ki_67的表达，并分析肿瘤组织中MUM1蛋白表达与ki_67增殖指数的关系。结果： 1例T_LBL/L(1/9，11.11％)、9例ALCL(9/12，75.0％)和26例PTL(26/37，70.27％)组织中MUM1蛋白的表达呈阳性。MUM1蛋白在T_LBL/L中的阳性表达率明显低于ALCL组和PTL组 (P<0.05)，而在ALCL与PTL间的差别无统计学意义(P>0.05)。MUM1蛋白阳性病例的ki_67增殖指数(53.61±23.83)％与MUM1阴性组(53.27±21.23)％相比，其差异无统计学意义(P>0.05)。结论： MUM1蛋白在T细胞淋巴瘤中的表达可能与细胞活化有关，与肿瘤细胞的增殖可能无直接关系

关键词: T细胞淋巴瘤, MUM1蛋白, ki_67增殖指数

Abstract: OBJECTIVE: To investigate the expression of MUM1 protein in T_cell lymphoma and its relationship with tumor cell proliferation. METHODS: The expressions of MUM1 protein and ki_67 in 58 specimens of T_NHL were analyzed by immunohistochemistry, including 9 cases of precursor T lymphoblastic lymphoma/leukemia(T_LBL/L),12 cases of anaplastic large T cell lymphoma(ALCL) and 37 cases of peripheral T cell lymphoma(PTL). Two cases of reactive hyperplastic lymphadenitis were used as comparison. We also analysed the relationship between MUM1 protein in tumor and ki_67 proliferation index. RESULTS: MUM1 protein expression was positive in 1 of 9 T_LBL/L, 9 of 12 ALCL and 26 of 37 PTL by immunohistochemistry.The expression rate of MUM1 protein in T_LBL/L was significantly lower than that in ALCL and PTL(P<0.05). The expression rate of MUM1 protein was similar in ALCL and PTL(P>0.05). There was no significant difference in MUM1 positive group of ki_67 proliferation index(53.61±23.83)％ compared with MUM1 negative group (53.27±21.23)％(P>0.05). CONCLUSION: The expression of MUM1 in T cell lymphoma may be associated with cell activation but not directly related to the proliferation of tumor cells.

Key words: T_cell lymphoma, MUM1 protein, ki_67 cell proliferation index

王素芬, 黄卡特, 陈　霖, 杨开颜. T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系[J]. 癌变·畸变·突变, 2010, 22(6): 458-461.

WANG Su-fen, HUANG Ka-te, CHEN Lin, YANG Kai-yan. Expression of MUM1 protein in T_cell lymphoma and its relationship with cell proliferation[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(6): 458-461.

T细胞淋巴瘤中MUM1蛋白的表达及其与细胞增殖的关系

Expression of MUM1 protein in T_cell lymphoma and its relationship with cell proliferation

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