粤东地区妇女人乳头瘤病毒感染情况和亚型分布及其与宫颈癌的关系

doi:10.3969/j.issn.1004-616x.2017.03.013

癌变·畸变·突变 ›› 2017, Vol. 29 ›› Issue (3): 226-229.doi: 10.3969/j.issn.1004-616x.2017.03.013

粤东地区妇女人乳头瘤病毒感染情况和亚型分布及其与宫颈癌的关系

沈伶¹, 许丽璇¹, 李小平¹, 胡桂英², 麦碧², 纪璇³, 粟丽¹

1.汕头大学医学院第一附属医院妇产科, 广东汕头 515031;
2.广东省妇幼保健院妇科, 广东广州 510010;
3.汕头大学医学院第一附属医院中医科, 广东汕头 515031

收稿日期:2016-11-25 修回日期:2017-01-19 出版日期:2017-05-31 发布日期:2017-05-31
通讯作者: 栗丽,E-mail:lili780929@163.com E-mail:lili780929@163.com
作者简介:沈伶,E-mail:shenling0627@sina.com。

Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population

SHEN Ling¹, XU Lixuan¹, LI Xiaoping¹, HU Guiying², MAI Bi², JI Xuan³, LI Li¹

1. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Medical College of Shantou University, Shantou 515031;
2. Department of Gynecology, Guangdong Provincial Maternity and Child Care Center, Guagnzhou 510010;
3. Department of Traditional Chinese Medicine, The First Affiliated Hospital of Medical College of Shantou University, Shantou 515031, Guangdong, China

Received:2016-11-25 Revised:2017-01-19 Online:2017-05-31 Published:2017-05-31

摘要/Abstract

摘要： 目的：检测粤东地区妇女人乳头瘤病毒（HPV）感染情况及亚型分布，探讨其与宫颈癌的关系。方法：选取2015年10月-2016年9月粤东地区7家三级医院30 000例行宫颈筛查的妇女作为研究对象。收集所有对象宫颈脱落细胞，采用HybriMax方法对HPV感染情况进行检测。对8 739例宫颈病变患者进行宫颈组织活检与HPV分型。比较分析不同病变类型以及年龄段HPV感染率与亚型分布。结果：脱落细胞检查个体中，HPV阳性者9 000例，感染率为30.00%。在8 739例行宫颈活检的宫颈病变患者中，HPV感染率为58.29%（5 094/8 739），慢性宫颈炎中HPV感染率为40.00%（1 088/2 720），CINⅠ中为53.59%（1 396/2 605），CINⅡ/Ⅲ中为71.61%（1 647/2 300），宫颈癌中为86.45%（963/1 114）。在各种宫颈病变中，HPV 16、18、33、58、52是最常见的高危亚型，感染率依次是14.02%、6.28%、5.23%、4.46%、3.71%。在宫颈癌患者中，最常见的亚型是HPV 16； ≥ 60岁的人群中HPV感染率最高，达到49.92%。结论：粤东地区HPV感染最常见的亚型为16、18、33、58、52型，宫颈病变程度越重，HPV的感染率越高。在宫颈癌患者中，HPV 16是最为常见的亚型，中老年患者的HPV感染率高于年轻人，单一感染可能更易导致宫颈癌的发生。

关键词: 粤东地区, 人乳头瘤病毒, 亚型分布, 宫颈癌

Abstract: OBJECTIVE:To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30 000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8 739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00% (9 000/30 000) of women were HPV positive,the frequency of HPV infection was 58.29% (5 094/8 739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1 088/2 720),patients with CIN I was 53.59%(1 396/2 605),patients with CIN was Ⅱ/Ⅲ 71.61% (1 647/2 300) and patients with cervical carcinoma was 86.45%(963/1 114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71% (324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.

Key words: Chaoshan area, human papilloma virus, genotype, cervical carcinoma

中图分类号:

R737.33

沈伶, 许丽璇, 李小平, 胡桂英, 麦碧, 纪璇, 粟丽. 粤东地区妇女人乳头瘤病毒感染情况和亚型分布及其与宫颈癌的关系[J]. 癌变·畸变·突变, 2017, 29(3): 226-229.

SHEN Ling, XU Lixuan, LI Xiaoping, HU Guiying, MAI Bi, JI Xuan, LI Li. Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 226-229.

参考文献

[1] YILDIRIM J G,ARABACI Z. Innovations in HPV vaccination and roles of nurses in cervical cancer prevention[J]. Asian Pac J Cancer Prev,2014,15(23):10053-10056.
[2] NAKAGAWA J T,SCHIRMER J,BARBIERI M. Human papillomavirus(HPV) and uterine cervical cancer[J]. Rev Bras Enferm,2010,63(2):307-311.
[3] STEBEN M,DUARTE-FRANCO E. Human papillomavirus infection:epidemiology and pathophysiology[J]. Gynecol Oncol, 2011,107(Sup 1):2-5.
[4] VAN DER HEIJDEN E,LOPES A D,BRYANT A,et al. Follow-up strategies after treatment (large loop excision of the transformation zone (LLETZ) for cervical intraepithelial neoplasia (CIN):Impact of human papillomavirus (HPV) test[J]. Cochrane Database Syst Rev,2015,1:CD010757.
[5] NOWAKOWSKI A,DE-SOUZA S C,JACH R,et al. HPV-type distribution and reproducibility of histological diagnosis in cervical neoplasia in Poland[J]. Pathol Oncol Res,2015, 21(3):703-711.
[6] LAI C Y,WU W W,TSAI S Y,et al. The effectiveness of a facebook-assisted teaching method on knowledge and attitudes about cervical cancer prevention and HPV vaccination intention among female adolescent students in Taiwan[J]. Health Educ Behav,2015,42(3):352-360.
[7] GRCE M,MATOVINA M,MILUTIN-GASPEROV N,et al. Advances in cervical cancer control and future perspectives[J]. Coll Antropol,2010,34(2):731-736.
[8] THABET M,HEMIDA R,HASAN M,et al. Human papillomavirus (HPV) is not the main cause of preinvasive and invasive cervical canceramong patients in Delta Region,Egypt[J]. J Exp Ther Oncol,2014,10(4):247-253.
[9] DONGMEI W U,LIN CAI,MENG HUANG,et al. Prevalence of genital human papillomavirus infection and genotypes among women from Fujian province,PR China[J]. Eur J Obstet Gynecol Reprod Biol,2010,151(1):86.
[10] LIU X,ZHANG S,RUAN Q,et al. Prevalence and type distribution of human papillomavirus in women with cervical lesions in Liaoning province,China[J]. Int J Gynecol Cancer, 2010,20(1):147.
[11] 亚力坤·穆罕默德,玛依努尔·尼牙孜,韩莉莉,等. 中国妇产科临床杂志,2014,15(1):6-9.

[1]	王晓舟, 李洪石, 于溪, 魏宁, 王梓瑛, 赫丽杰. 青藤碱对HPV阳性宫颈癌SiHa细胞增殖和侵袭的影响[J]. 癌变·畸变·突变, 2021, 33(6): 442-445.
[2]	方磊, 杨涛, 盛磊, 木塔力甫·艾买提, 齐鑫鑫, 艾尼娃尔·艾克木, 伊力亚尔·尼加提. 黑种草子总皂苷对人宫颈癌SiHa细胞生物学行为的影响[J]. 癌变·畸变·突变, 2021, 33(2): 143-148,152.
[3]	兰莉, 陈海丽, 徐蕾. RBMS3-AS3对宫颈癌细胞增殖、凋亡和侵袭的影响及作用机制[J]. 癌变·畸变·突变, 2020, 32(6): 438-443.
[4]	王媛媛, 陈依超, 郑洁, 彭燕燕, 王少洪. 汕头市妇女HPV-52感染与宫颈鳞状上皮病变的关系[J]. 癌变·畸变·突变, 2020, 32(4): 304-308.
[5]	盛磊, 武贵臻, 热娜古丽·热依木, 艾尼娃尔·艾克木. 新疆黑种草子总黄酮体外抗宫颈癌活性研究[J]. 癌变·畸变·突变, 2019, 31(5): 385-391.
[6]	徐苗, 张天一, 田菲菲. PD-1/PD-L1信号通路抑制剂在宫颈癌治疗中的研究进展[J]. 癌变·畸变·突变, 2019, 31(5): 417-420.
[7]	郝轶, 袁建林, 肖悦, 李卉, 郭霞. 3种不同的HPV型别宫颈癌细胞株分泌蛋白非标记定量技术分析[J]. 癌变·畸变·突变, 2018, 30(5): 354-358,364.
[8]	迪拉热·力迪甫, 木塔力甫·艾买提, 盛磊, 古扎力努尔买提沙, 艾尔肯·肉孜比拉力, ABULIZI Abudula. HPV16编码蛋白与宫颈癌细胞内CALCA和TFPI-2表达的关系[J]. 癌变·畸变·突变, 2017, 29(6): 431-436.
[9]	宋淑芳, 常海平, 杨彩容, 赵荣伟, 张龙, 任杰, 郑健. 慢病毒介导的TPX2基因沉默对人宫颈癌HeLa细胞系增殖、迁移和细胞周期的影响及机制[J]. 癌变·畸变·突变, 2017, 29(5): 329-334,339.
[10]	刘好, 赵滢滢, 金平, 许改霞, 郭宇然, 张可, 王晓梅, 张蕾. 组蛋白去乙酰化酶抑制剂联合紫杉醇抑制宫颈癌细胞增殖的体外实验[J]. 癌变·畸变·突变, 2017, 29(5): 335-339.
[11]	丁立新, 赵现哲, 姜晓燕, 丁库克. 宫颈癌辐射敏感性相关基因的研究进展[J]. 癌变·畸变·突变, 2017, 29(5): 394-396,401.
[12]	刘平. 长链非编码RNA XIST和miR-101-3p在子宫颈癌组织中的表达及关系[J]. 癌变·畸变·突变, 2017, 29(2): 121-124.
[13]	张雪杉, 缪芳, 曹晏宁, 张晓姝. 婆罗双树样基因2干扰对宫颈癌HeLa细胞增殖和凋亡的影响[J]. 癌变·畸变·突变, 2016, 28(5): 359-363,368.
[14]	盛磊, 茹明芳, 武贵臻, 杨云, 阿布力孜·阿布杜拉. 维吾尔族妇女宫颈癌患者的免疫状态及其与临床病理因素的关系[J]. 癌变·畸变·突变, 2016, 28(5): 369-371,376.
[15]	栗丽, 胡桂英, 吴宇丹, 沈伶. 薄层液基细胞学联合HPV-DNA检测在粤东地区宫颈癌筛查中的临床价值[J]. 癌变·畸变·突变, 2016, 28(4): 281-283,291.

粤东地区妇女人乳头瘤病毒感染情况和亚型分布及其与宫颈癌的关系

Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价