癌变·畸变·突变 ›› 2017, Vol. 29 ›› Issue (3): 226-229.doi: 10.3969/j.issn.1004-616x.2017.03.013

• 肿瘤防治 • 上一篇    下一篇

粤东地区妇女人乳头瘤病毒感染情况和亚型分布及其与宫颈癌的关系

沈伶1, 许丽璇1, 李小平1, 胡桂英2, 麦碧2, 纪璇3, 粟丽1   

  1. 1.汕头大学医学院第一附属医院妇产科, 广东 汕头 515031;
    2.广东省妇幼保健院妇科, 广东 广州 510010;
    3.汕头大学医学院第一附属医院中医科, 广东 汕头 515031
  • 收稿日期:2016-11-25 修回日期:2017-01-19 出版日期:2017-05-31 发布日期:2017-05-31
  • 通讯作者: 栗丽,E-mail:lili780929@163.com E-mail:lili780929@163.com
  • 作者简介:沈伶,E-mail:shenling0627@sina.com。

Prevalence of human papilloma-virus genotypes and associated risk of cervical carcinoma in Chaoshan population

SHEN Ling1, XU Lixuan1, LI Xiaoping1, HU Guiying2, MAI Bi2, JI Xuan3, LI Li1   

  1. 1. Department of Gynecology and Obstetrics, The First Affiliated Hospital of Medical College of Shantou University, Shantou 515031;
    2. Department of Gynecology, Guangdong Provincial Maternity and Child Care Center, Guagnzhou 510010;
    3. Department of Traditional Chinese Medicine, The First Affiliated Hospital of Medical College of Shantou University, Shantou 515031, Guangdong, China
  • Received:2016-11-25 Revised:2017-01-19 Online:2017-05-31 Published:2017-05-31

摘要: 目的:检测粤东地区妇女人乳头瘤病毒(HPV)感染情况及亚型分布,探讨其与宫颈癌的关系。方法:选取2015年10月-2016年9月粤东地区7家三级医院30 000例行宫颈筛查的妇女作为研究对象。收集所有对象宫颈脱落细胞,采用HybriMax方法对HPV感染情况进行检测。对8 739例宫颈病变患者进行宫颈组织活检与HPV分型。比较分析不同病变类型以及年龄段HPV感染率与亚型分布。结果:脱落细胞检查个体中,HPV阳性者9 000例,感染率为30.00%。在8 739例行宫颈活检的宫颈病变患者中,HPV感染率为58.29%(5 094/8 739),慢性宫颈炎中HPV感染率为40.00%(1 088/2 720),CINⅠ中为53.59%(1 396/2 605),CINⅡ/Ⅲ中为71.61%(1 647/2 300),宫颈癌中为86.45%(963/1 114)。在各种宫颈病变中,HPV 16、18、33、58、52是最常见的高危亚型,感染率依次是14.02%、6.28%、5.23%、4.46%、3.71%。在宫颈癌患者中,最常见的亚型是HPV 16; ≥ 60岁的人群中HPV感染率最高,达到49.92%。结论:粤东地区HPV感染最常见的亚型为16、18、33、58、52型,宫颈病变程度越重,HPV的感染率越高。在宫颈癌患者中,HPV 16是最为常见的亚型,中老年患者的HPV感染率高于年轻人,单一感染可能更易导致宫颈癌的发生。

关键词: 粤东地区, 人乳头瘤病毒, 亚型分布, 宫颈癌

Abstract: OBJECTIVE:To determine genotype-specific distribution of human papillomavirus (HPV) in women and to identify its relationship with cervical carcinoma in Chaoshan population. METHODS:Data from 30 000 women who were subjected to cervical HPV DNA testing were retrospectively evaluated in a hospital-based study. A total of 8 739 women,who had both HPV typing and pathological examination,were investigated. RESULTS:Overall,30.00% (9 000/30 000) of women were HPV positive,the frequency of HPV infection was 58.29% (5 094/8 739) in women with cervical cytological abnormalities,and the infection rate for patients with chronic cervicitis was 40.00% (1 088/2 720),patients with CIN I was 53.59%(1 396/2 605),patients with CIN was Ⅱ/Ⅲ 71.61% (1 647/2 300) and patients with cervical carcinoma was 86.45%(963/1 114). HPV 16 (14.02%) was the most common type for all cervical cytological abnormalities,followed by 18 type 6.28%(549),33 type 5.23%(457),58 type 4.46%(390) and 52 type 3.71% (324),while the more common HPV 16 type in cervical carcinoma with the highest infection (49.92%) was in women aged over 60. CONCLUSION:Our data indicate a relatively high prevalence of HPV 16,52,33,58 and 18 in women,their positive association with cervical cytological abnormalities. Specifically,the HPV 16 was the most common subtype among senior women with cervical carcinoma.

Key words: Chaoshan area, human papilloma virus, genotype, cervical carcinoma

中图分类号: