[1] OSTROM Q T,GITTLEMAN H,FULOP J,et al. CBTRUS statistical report:Primary brain and central nervous system tumors diagnosed in the United States in 2008-2012[J]. Neuro Oncol,2015,17(Sup 4):1-62.[2] OSUKA S,VAN MEIR E G. Overcoming therapeutic resistance in glioblastoma:the way forward[J]. J Clin Invest,2017,127(2):415-426.[3] BRADSHAW A,WICKREMSEKERA A,TAN S T,et al. Cancer stem cell hierarchy in glioblastoma multiforme[J]. Front Surg,2016,3:21.[4] CODRICI E,ENCIU A M,POPESCU I D,et al. Glioma stem cells and their microenvironments:providers of challenging therapeutic targets[J]. Stem Cells Int,2016,2016:5728438.[5] DENG Q,TANG D G. Androgen receptor and prostate cancer stem cells:biological mechanisms and clinical implications[J]. Endocr Relat Cancer,2015,22(6):T209-T220.[6] STOIAN M,STOICA V,RADULIAN G. Stem cells and colorectal carcinogenesis[J]. J Med Life,2016,9(1):6-11.[7] CODONY-SERVAT J,VERLICCHI A,ROSELL R. Cancer stem cells in small cell lung cancer[J]. Transl Lung Cancer Res,2016,5(1):16-25.[8] SUNDAR S J,HSIEH J K,MANJILA S,et al. The role of cancer stem cells in glioblastoma[J]. Neurosurg Focus,2014,37(6):E6.[9] BISCHOF J,WESTHOFF M A,WAGNER J E,et al. Cancer stem cells:The potential role of autophagy,proteolysis,and cathepsins in glioblastoma stem cells[J]. Tumour Biol,2017,39(3):1393397437.[10] ABOU-ANTOUN T J,HALE J S,LATHIA J D,et al. Brain cancer stem cells in adults and children:cell biology and therapeutic implications[J]. Neurotherapeutics,2017.[11] ANIDO J,SAEZ-BORDERIAS A,GONZALEZ-JUNCA A,et al. TGF-beta receptor inhibitors target the CD44(high)/Id1(high) glioma-initiating cell population in human glioblastoma[J]. Cancer Cell,2010,18(6):655-668.[12] VELPULA K K,REHMAN A A,CHELLUBOINA B,et al. Glioma stem cell invasion through regulation of the interconnected ERK,integrin alpha6 and N-cadherin signaling pathway[J]. Cell Signal,2012,24(11):2076-2084.[13] THON N,DAMIANOFF K,HEGERMANN J,et al. Presence of pluripotent CD133+ cells correlates with malignancy of gliomas[J]. Mol Cell Neurosci,2010,43(1):51-59.[14] GUO Y,LIU S,WANG P,et al. Expression profile of embryonic stem cell-associated genes Oct4,Sox2 and Nanog in human gliomas[J]. Histopathology,2011,59(4):763-775.[15] LIEBELT B D,SHINGU T,ZHOU X,et al. Glioma stem cells:signaling,microenvironment,and therapy[J]. Stem Cells Int,2016,2016:7849890.[16] CAPILLA-GONZALEZ V,BONSU J M,REDMOND K J,et al. Implications of irradiating the subventricular zone stem cell niche[J]. Stem Cell Res,2016,16(2):387-396.[17] LATHIA J D,GALLAGHER J,MYERS J T,et al. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells[J]. PLoS One,2011,6(9):e24807.[18] HUANG Q,ZHANG Q B,DONG J,et al. Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor,and both can be maintained long-term in vitro[J]. BMC Cancer,2008,8:304.[19] SINGH S K,CLARKE I D,TERASAKI M,et al. Identification of a cancer stem cell in human brain tumors[J]. Cancer Res,2003,63(18):5821-5828.[20] TEODORCZYK M,SCHMIDT M H. Notching on cancer's door:Notch signaling in brain tumors[J]. Front Oncol,2014,4:341.[21] BORGGREFE T,LAUTH M,ZWIJSEN A,et al. The Notch intracellular domain integrates signals from Wnt,Hedgehog,TGFbeta/BMP and hypoxia pathways[J]. Biochim Biophys Acta,2016,1863(2):303-313.[22] DHANESH S B,SUBASHINI C,JAMES J. Hes1:the maestro in neurogenesis[J]. Cell Mol Life Sci,2016,73(21):4019-4042.[23] MAJIDINIA M,ALIZADEH E,YOUSEFI B,et al. Co-inhibition of Notch and NF-kappaB signaling pathway decreases proliferation through downregulating IkappaB-alpha and Hes-1 expression in human ovarian cancer OVCAR-3 cells[J]. Drug Res (Stuttg),2017,67(1):13-19.[24] ZHOU Z D,KUMARI U,XIAO Z C,et al. Notch as a molecular switch in neural stem cells[J]. IUBMB Life,2010,62(8):618-623.[25] HUANG Y,TAN S. Direct lineage conversion of astrocytes to induced neural stem cells or neurons[J]. Neurosci Bull,2015,31(3):357-367.[26] FAN X,MATSUI W,KHAKI L,et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors[J]. Cancer Res,2006,66(15):7445-7452.[27] GUNTHER H S,SCHMIDT N O,PHILLIPS H S,et al. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria[J]. Oncogene,2008,27(20):2897-2909.[28] BRANDT W D,SCHRECK K C,BAR E E,et al. Notch signaling activation in pediatric low-grade astrocytoma[J]. J Neuropathol Exp Neurol,2015,74(2):121-131.[29] 徐菲,陈东,胡继良. 人脑胶质瘤干细胞增殖中NOTCH信号的调控作用[J]. 中国医学创新,2016(21):18-21.[30] PUROW B W,HAQUE R M,NOEL M W,et al. Expression of Notch-1 and its ligands,Delta-like-1 and Jagged-1,is critical for glioma cell survival and proliferation[J]. Cancer Res,2005,65(6):2353-2363.[31] ULASOV I V,NANDI S,DEY M,et al. Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133+ glioma stem cells to temozolomide therapy[J]. Mol Med,2011,17(1-2):103-112.[32] LIEBELT B D,SHINGU T,ZHOU X,et al. Glioma stem cells:signaling,microenvironment,and therapy[J]. Stem Cells Int,2016,2016:7849890.[33] KOURY J,ZHONG L,HAO J. Targeting signaling pathways in cancer stem cells for cancer treatment[J]. Stem Cells Int,2017,2017:2925869.[34] HU Y Y,FU L A,LI S Z,et al. Hif-1alpha and Hif-2alpha differentially regulate Notch signaling through competitive interaction with the intracellular domain of Notch receptors in glioma stem cells[J]. Cancer Lett,2014,349(1):67-76.[35] XIAO Z,ZHANG J,PENG X,et al. The Notch gamma-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-beta/Smad2/3 signaling pathway activation[J]. Int J Biochem Cell Biol,2014,55:65-71.[36] WEISS G J. Doubling down with inhibitors of Notch and Hedgehog signaling pathways[J]. J Thorac Oncol,2012,7(16 Suppl 5):S409-S410.[37] KAHLERT U D,CHENG M,KOCH K,et al. Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells[J]. Int J Cancer,2016,138(5):1246-1255.[38] QIU M,PENG Q,JIANG I,et al. Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells[J]. Cancer Lett,2013,328(2):261-270.[39] TAKEBE N,NGUYEN D,YANG S X. Targeting notch signaling pathway in cancer:clinical development advances and challenges[J]. Pharmacol Ther,2014,141(2):140-149. |