线粒体关联性内质网膜与细胞Ca2+依赖性死亡的研究进展

doi:10.3969/j.issn.1004-616x.2018.03.016

癌变·畸变·突变 ›› 2018, Vol. 30 ›› Issue (3): 242-247.doi: 10.3969/j.issn.1004-616x.2018.03.016

• 综述 • 上一篇

线粒体关联性内质网膜与细胞Ca²⁺依赖性死亡的研究进展

姚欢, 林育纯, 林忠宁

分子疫苗学和分子诊断学国家重点实验室, 厦门大学公共卫生学院, 福建厦门 361102

收稿日期:2018-01-16 修回日期:2018-04-09 出版日期:2018-05-30 发布日期:2018-05-30
通讯作者: 林忠宁,E-mail:linzhn@xmu.edu.cn E-mail:linzhn@xmu.edu.cn
作者简介:姚欢,E-mail:m15159254182@163.com。
基金资助:
国家自然科学基金（81773465，81573181，81472997）；福建省自然科学基金项目（2015J01344）

Received:2018-01-16 Revised:2018-04-09 Online:2018-05-30 Published:2018-05-30

摘要/Abstract

摘要： 线粒体关联性内质网膜（MAM）是线粒体和内质网发生交互作用的功能平台。研究发现有几十种蛋白质富集于两细胞器外膜之间，作为MAM蛋白质组成构成连接结构，功能上与Ca²⁺信号传导等密切相关，影响生理或外源环境因素诱导的细胞转归和命运结局。文章重点阐述了MAM组成结构和功能调节及其在细胞Ca²⁺依赖性死亡中的作用。

关键词: 线粒体关联性内质网膜, 钙信号, 细胞Ca²⁺依赖性死亡, 细胞转归

中图分类号:

姚欢, 林育纯, 林忠宁. 线粒体关联性内质网膜与细胞Ca²⁺依赖性死亡的研究进展[J]. 癌变·畸变·突变, 2018, 30(3): 242-247.

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线粒体关联性内质网膜与细胞Ca²⁺依赖性死亡的研究进展

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