组蛋白修饰在砷中毒发病机制中的研究进展

doi:10.3969/j.issn.1004-616x.2019.02.011

摘要/Abstract

摘要： 地方性砷中毒是由于特定地区的居民从饮水、空气或食物中长期摄入过量的砷化物所引起的涉及全身多器官损害的生物地球化学性疾病，因其发病机制不明确、缺乏特效药及早期生物学标志物等因素，长期以来成为政府和科技工作者研究的重点和热点。表观遗传修饰不仅与砷暴露呈现相关性，又可通过调控关键分子的表达参与砷诱导的早期损伤，成为近年来砷中毒机制研究的重要方向。作为表观遗传修饰的重要模式之一，组蛋白修饰能稳定激活或抑制基因的表达，有望为地方性砷中毒提供新的治疗靶点。但组蛋白修饰是如何调控砷诱导关键基因的表达参与砷中毒的发生发展，以及与砷中毒机制之间的关系，有待深入研究，现将组蛋白修饰在砷中毒发病机制的研究进展进行综述。

关键词: 地方性砷中毒, 砷诱导, 组蛋白修饰, 遗传损伤, 氧化应激

中图分类号:

R994.6

侯腾, 马璐, 张爱华. 组蛋白修饰在砷中毒发病机制中的研究进展[J]. 癌变·畸变·突变, 2019, 31(2): 153-156.

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