弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测的临床意义

doi:10.3969/j.issn.1004-616x.2019.03.010

癌变·畸变·突变 ›› 2019, Vol. 31 ›› Issue (3): 227-230.doi: 10.3969/j.issn.1004-616x.2019.03.010

弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测的临床意义

马鸣¹, 焦文静¹, 王延海², 颜晰¹, 张超¹, 张金艳¹

1. 河北医科大学第四医院检验科, 河北石家庄 050011;
2. 河北省军区门诊部, 河北石家庄 050011

收稿日期:2018-09-26 修回日期:2018-12-19 出版日期:2019-05-31 发布日期:2019-05-31
通讯作者: 张金艳,E-mail:jinyanzhang66@sina.com E-mail:jinyanzhang66@sina.com
作者简介:马鸣,E-mail:maming19830419@163.com。
基金资助:
河北省卫计委指令性课题（20160171）

Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma

MA Ming¹, JIAO Wenjing¹, WANG Yanhai², YAN Xi¹, ZHANG Chao¹, ZHANG Jinyan¹

1. The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;
2. Hebei Military Outpatient Department, Shijiazhuang 050011, Hebei, China

Received:2018-09-26 Revised:2018-12-19 Online:2019-05-31 Published:2019-05-31

摘要/Abstract

摘要： 目的：探讨弥漫大B细胞淋巴瘤（DLBCL）患者外周血清IL-24及IL-6的浓度及其临床意义。方法：收集43例DLBCL患者和33例正常对照人群外周血血清，ELISA法检测IL-24及IL-6的浓度，分析血清IL-24及IL-6浓度与患者临床病理指标之间的关系；并计算患者的国际预后指数（IPI）。结果：与正常对照组[IL-24浓度为（58.32±11.81）μg/mL，IL-6为（24.63±7.73）μg/mL]相比，DLBCL患者血清IL-24浓度[（42.18±8.48）μg/mL]明显降低（P<0.01），而IL-6浓度[（45.29±12.71）μg/mL]明显升高（P<0.01），且二者浓度呈明显负相关（r=-0.414，P<0.05）；同时血清IL-24及IL-6浓度与患者临床分期、肿瘤细胞侵犯骨髓状态及IPI均密切相关（P<0.01），而与患者年龄及性别均无明显相关关系（P>0.05）。发生骨髓转移组患者血清中IL-24较正常对照组和未转移组均明显降低（P<0.01），而IL-6浓度明显升高（P<0.01）；同时随着骨髓转移程度的增加，该趋势更为明显。IPI指数>2的患者，外周血IL-24浓度较IPI指数<2的患者明显降低，而IL-6浓度明显升高（P<0.01）。结论：DLBCL患者血清IL-24浓度较低及IL-6浓度较高可能是患者临床症状较重，预后较差的预测指标。血清IL-24及IL-6浓度测定可作为DLBCL的辅助诊断及监测指标，为临床治疗提供科学依据。

关键词: 弥漫大B细胞淋巴瘤, IL-24, IL-6, 血清肿瘤标志物

Abstract: OBJECTIVE:To investigate the significance of IL-24 and IL-6 concentrations in serum of patients with Diffuse large B-cell lymphoma (DLBCL). METHODS:Concentrations of serum IL-24 and IL-6 were detected using the ELISA assay. The relationship between the concentrations and the clinicopathological parameters in 43 cases of DLBCL patients was analyzed. RESULTS:Compared with the control patients,the concentrations of IL-24 and IL-6:(58.32 ±11.81) and (24.63 ±7.73) μg/mL, respectively, and the IL-24 concentration:(42.18 ±8.48) μg/mL in the DLBCL patients were significantly lower, whereas the IL-6 concentration:(45.29±12.71) μg/mL was significantly higher (P<0.01). Furthermore,the concentrations of IL-24 was significantly lower,while the IL-6 was higher in the serum of the patients who had bone marrow invasion than those without the invasion (P<0.01). The similar results were also shown in the patients with the high IPI scores (P<0.01). These findings suggest that the low IL-24 and high IL-6 concentrations may be predictors for poor clinical status and prognosis of DLBCL patients. CONCLUSION:Detection of the serum IL-24 and IL-6 concentrations may be useful as auxiliary diagnosis for improved clinical therapy in DLBCL.

Key words: diffuse large B-cell lymphoma, IL-24, IL-6, serum tumor marker

中图分类号:

R825.5

马鸣, 焦文静, 王延海, 颜晰, 张超, 张金艳. 弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测的临床意义[J]. 癌变·畸变·突变, 2019, 31(3): 227-230.

MA Ming, JIAO Wenjing, WANG Yanhai, YAN Xi, ZHANG Chao, ZHANG Jinyan. Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 227-230.

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弥漫大B细胞淋巴瘤患者血清IL-24及IL-6浓度检测的临床意义

Clinical values of serum IL-24 and IL-6 concentrations for patients with diffuse large B-cell lymphoma

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