甲基汞暴露致学习记忆功能障碍作用机制的研究进展

doi:10.3969/j.issn.1004-616x.2020.06.016

摘要/Abstract

摘要： 亲脂性的甲基汞是一种神经毒性物质，极易通过胎盘屏障进入胎儿体内，因此，胎儿和婴幼儿的中枢神经系统是其发挥神经毒性效应的主要靶点。目前，许多研究已证实甲基汞暴露会导致子代的神经发育异常，致使大脑的学习记忆功能障碍，但其机制仍需进一步探究。本文总结了近几年来国内外关于氧化应激、谷氨酸过度激活、NMDAR异常表达、铁死亡、自噬和表观遗传修饰等在甲基汞暴露致学习记忆功能障碍的作用机制，为甲基汞致神经损害的机制研究提供新思路，并就未来的相关研究提出展望。

关键词: 甲基汞, 氧化应激, 谷氨酸, 铁死亡, 自噬, 表观遗传修饰

中图分类号:

R595.2

张力, 张爱华, 王文娟. 甲基汞暴露致学习记忆功能障碍作用机制的研究进展[J]. 癌变·畸变·突变, 2020, 32(6): 490-493.

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