叶酸对阿尔茨海默病的影响及其机制研究进展

doi:10.3969/j.issn.1004-616x.2021.04.014

癌变·畸变·突变 ›› 2021, Vol. 33 ›› Issue (4): 317-320,325.doi: 10.3969/j.issn.1004-616x.2021.04.014

叶酸对阿尔茨海默病的影响及其机制研究进展

李剑飞¹, 郭锡汉¹, 薛京伦², 汪旭¹

1. 云南师范大学生命科学学院, 云南昆明 650500;
2. 复旦大学遗传学研究所, 上海 201438

收稿日期:2021-06-07 修回日期:2021-06-25 出版日期:2021-07-30 发布日期:2021-07-29
通讯作者: 汪旭,E-mail:wangxu@fudan.edu.cn E-mail:wangxu@fudan.edu.cn
作者简介:李剑飞,E-mail:1205085222@qq.com。
基金资助:
国家自然科学基金（31860301，31900410）；云南省基础研究计划项目（202001AU070055，202101AT070112）；云南师范大学优秀青年学者项目

Received:2021-06-07 Revised:2021-06-25 Online:2021-07-30 Published:2021-07-29

摘要/Abstract

摘要： 叶酸是一碳代谢的一组关键微营养素，对DNA结构和功能的维护有重要作用。叶酸缺乏和代谢异常是DNA合成和甲基化紊乱的诱因之一。阿尔茨海默病（AD）是典型的由遗传和环境因素共同作用引发的神经退行性疾病，β-淀粉样蛋白（Aβ）聚集和微管结合蛋白（tau）过度磷酸化是AD的主要病理特征。分子流行病学研究和动物学实验表明叶酸缺乏与人体认知能力下降和AD患病风险具有密切关联。本文综述了叶酸对AD患病风险的影响及其机制研究进展，旨在从营养基因组学角度为防范AD提供新思路。

关键词: 叶酸, 阿尔茨海默病, β-淀粉样蛋白, tau蛋白

中图分类号:

R329.2+8

李剑飞, 郭锡汉, 薛京伦, 汪旭. 叶酸对阿尔茨海默病的影响及其机制研究进展[J]. 癌变·畸变·突变, 2021, 33(4): 317-320,325.

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叶酸对阿尔茨海默病的影响及其机制研究进展

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