人群PIG-A基因突变测定的研究进展

doi:10.3969/j.issn.1004-616x.2021.05.015

摘要/Abstract

摘要： 暴露于环境危险因素对人群健康的影响广泛，检测有效的生物标志物有助于评估人群暴露的健康风险。近年来，PIG-A基因突变测定被尝试用于评估人群暴露于环境因素的致突变效应。本文综述了健康人群中PIG-A基因突变测定方法、突变水平、影响因素以及应用现状的研究进展，发现目前PIG-A基因突变测定方法技术可行，但检测结果的个体间变异较大，多项研究发现PIG-A基因突变率与年龄、性别等因素的关联并不一致，更多潜在的影响因素仍在探索中。今后有必要进行更大样本量的人群研究，获得人群的基线水平，明确机体因素和环境因素对个体间变异的作用。在应用时需结合同期健康对照和暴露前后的数据进行综合分析，促进该方法应用于人体真实暴露后的健康风险评估。

关键词: PIG-A, 基因突变, 人群研究, 生物标志, 健康风险评估

中图分类号:

李蕊瑞, 张立实, 陈锦瑶. 人群PIG-A基因突变测定的研究进展[J]. 癌变·畸变·突变, 2021, 33(5): 396-400.

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