夫精人工授精活产率的影响因素研究

doi:10.3969/j.issn.1004-616x.2023.01.005

癌变·畸变·突变 ›› 2023, Vol. 35 ›› Issue (1): 26-29.doi: 10.3969/j.issn.1004-616x.2023.01.005

夫精人工授精活产率的影响因素研究

张清健, 宋革, 祝晓丽, 詹泽虎, 蔡晓林, 李艳

国家卫生健康委员会男性生殖与遗传重点实验室, 广东省生殖科学研究所生殖中心, 广东广州 510600

收稿日期:2022-09-27 修回日期:2022-12-05 发布日期:2023-02-09
通讯作者: 宋革
作者简介:张清健,E-mail:1460124350@qq.com。
基金资助:
广东省医学科研基金项目(A2022326)；广东省生殖科学研究所项目(S2018010)

Factors that influence live-birth rates after artificial insemination with husbands' sperm

ZHANG Qingjian, SONG Ge, ZHU Xiaoli, ZHAN Zehu, CAI Xiaolin, LI Yan

Key Laboratory of Male Reproduction and Genetics of National Health Commission, Reproductive Center of Guangdong Provincial Reproductive Science Institute, Guangzhou 510600, Guangdong, China

Received:2022-09-27 Revised:2022-12-05 Published:2023-02-09

摘要/Abstract

摘要： 目的: 探讨夫精人工授精(AIH)活产率的影响因素。方法: 选择2011年1月—2021年9月在广东省生殖医院生殖中心治疗的1 232对夫妇，共计2 391个AIH周期，采用卡方检验和广义估计方程分析活产率的影响因素。结果: 女性年龄≥40岁[OR=0.270，95% CI(0.084，0.874)]显著降低授精妇女的活产率；而月经第3天促黄体生成素>8.00 IU/L[OR=1.734，95% CI(1.167，2.576)]、促排周期[OR=1.472，95% CI(1.037，2.090)]、每周期排卵3个[OR=1.567，95% CI(1.007，2.437)]和精子处理前前向运动精子总数>2×10⁷个[OR=2.232，95% CI(1.295，3.847)]显著提高授精妇女的活产率。结论: 女性年龄、月经第3天促黄体生成素浓度、治疗方案、每周期排卵数以及处理前前向运动精子总数影响夫精人工授精妇女的活产率。

关键词: 夫精人工授精, 活产率, 促黄体生成素, 广义估计方程

Abstract: OBJECTIVE: To understand influencing factors on live-birth rates after artificial insemination with husbands-- sperm (AIH). METHODS: The study included 2391 AIH cycles from January 2011 to September 2021 in a reproductive center of the Guangdong Provincial Reproductive Science Institute. The Chi-square and the generalized estimation equation (GEE) were used to analyze factors affecting the live-birth rates. RESULTS: Inseminated women who were ≥40 years old had significantly reduced live birth rates than the younger ones ([OR=0.270，95%CI(0.0840，0.874)]). On day 3 after insemination，menstrual luteinizing hormone (LH) >8.00 IU/L，the ovulation cycle，3 eggs ovulated per cycle and prewash total motile sperm >2×10⁷ significantly increased live birth rates of insemination women [OR=1.734，95%CI(1.167，2.576)；OR=1.472，95%CI(1.037，2.090)；OR=1.567，95%CI(1.007，2.437)；and OR=2.232，95%CI(1.295，3.847)，respectively. CONCLUSION: Our data indicate that age of females，day 3 menstrual LH levels，treatment protocols，ovulation numbers per cycle and prewash total motile sperm numbers significantly affected live-birth rates after AIH.

Key words: AIH, live birth rates, luteinizing hormone, generalized estimation equation

中图分类号:

S814.3

张清健, 宋革, 祝晓丽, 詹泽虎, 蔡晓林, 李艳. 夫精人工授精活产率的影响因素研究[J]. 癌变·畸变·突变, 2023, 35(1): 26-29.

ZHANG Qingjian, SONG Ge, ZHU Xiaoli, ZHAN Zehu, CAI Xiaolin, LI Yan. Factors that influence live-birth rates after artificial insemination with husbands' sperm[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(1): 26-29.

参考文献

[1] LA MARCA A, CAPUZZO M, IMBROGNO M G, et al. The complex relationship between female age and embryo euploidy[J]. Minerva Obstet Gynecol, 2021, 73(1):103-110.
[2] MCLERNON D J, LEE A J, MAHESHWARI A, et al. Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility[J]. Hum Reprod, 2019, 34(6):1126-1138.
[3] 雷淼, 黄铄, 罗莉, 等. 影响宫腔内人工授精活产率的临床因素分析[J]. 中华生殖与避孕杂志, 2022, 42(5):476-483.
[4] BALASCH J, FÁBREGUES F. Is luteinizing hormone needed for optimal ovulation induction-[J]. Curr Opin Obstet Gynecol, 2002, 14(3):265-274.
[5] BARROSO G, OEHNINGER S, MONZÓ A, et al. High FSH:LH ratio and low LH levels in basal cycle day 3:impact on follicular development and IVF outcome[J]. J Assist Reprod Genet, 2001, 18(9):499-505.
[6] CHEN C D, CHIANG Y T, YANG P K, et al. Frequency of low serum LH is associated with increased early pregnancy loss in IVF/ICSI cycles[J]. Reproductive Biomed Online, 2016, 33(4):449-457.
[7] 张清健, 宋革, 钟小英, 等. 16458个供精人工授精自然周期妊娠结局的多因素分析[J]. 中华生殖与避孕杂志, 2020, 40(8):620-628.
[8] 谷保霞, 郭海彬, 张合龙, 等. 影响夫精宫腔内人工授精妊娠成功率相关因素分析[J]. 中华实用诊断与治疗杂志, 2019, 33(4):340-342.
[9] HUANG S, WANG R, LI R, et al. Ovarian stimulation in infertile women treated with the use of intrauterine insemination:a cohort study from China[J]. Fertil Steril, 2018, 109(5):872-878.
[10] MANKUS E B, HOLDEN A E, SEEKER P M, et al. Prewash total motile count is a poor predictor of live birth in intrauterine insemination cycles[J]. Fertil Steril, 2019, 111(4):708-713.
[11] 徐景岭. 夫精人工授精过程中的精液质量评估[J]. 生殖与避孕, 2015, 35(9):650-654.

夫精人工授精活产率的影响因素研究

Factors that influence live-birth rates after artificial insemination with husbands' sperm

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价