卷烟烟气诱导慢性阻塞性肺疾病的评估模型和组学技术应用研究进展

doi:10.3969/j.issn.1004-616x.2025.01.013

摘要/Abstract

摘要： 慢性阻塞性肺疾病(COPD)是一种普遍存在的慢性呼吸道疾病，在全球范围内，COPD的发病率和死亡率持续上升，已成为主要的疾病死亡原因之一。卷烟烟气被认为是COPD发生和进展的危险因素之一，其涉及的机制异常复杂，包括氧化应激、炎症、蛋白酶-抗蛋白酶平衡紊乱、细胞凋亡，甚至免疫衰老等多个方面。本文综述了常见的卷烟烟气诱导COPD的体内外模型，以及其在基因组学、转录组学、蛋白质组学以及代谢组学方面的研究进展，为进行卷烟烟气诱导COPD的实验研究提供参考依据。

关键词: 卷烟烟气, 慢性阻塞性肺疾病, 评估模型, 组学技术, 生物标志物

中图分类号:

R994

冯博洋, 李翔, 李泽之, 谢复炜, 张晓兵. 卷烟烟气诱导慢性阻塞性肺疾病的评估模型和组学技术应用研究进展[J]. 癌变·畸变·突变, 2025, 37(1): 75-80.

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