癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (3): 170-172.doi: 10.3969/j.issn.1004-616x.1998.03.012

• 论著 • 上一篇    下一篇

昆明山海棠对人外周血淋巴细胞染色体的畸变效应

李练兵 蔡 敏 马明福 李新生 曾维三   

  1. 重庆市计划生育科学研究所  重庆400020
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-05-30 发布日期:1998-05-30

EFFECTS OF TRIPTERYGIUM HYPOGLAUCUM(LEVL) HUTCHON CHROMOSOME ABERRATION IN CULTURED HUMAN PERIPHERAL BLOOD LYMPHOCYTES

Li Lianbing , Cai Min ,Ma Mingfu ,Li Xiinsheng ,Zeng Weisan   

  1. Chongqing Family Planning Scientif ic Research Instit ute , Chongqing 400020
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

摘要: 本文报道昆明山海棠对人外周血淋巴细胞的染色体畸变效应测试结果。分别将昆明山海棠根部水提物( THH) 50 、100 、200 、400 、800μg/ ml 和乙醇提到物(ATH) 215 、25 、50 、100 和200μg/ ml 进行人外周血淋巴细胞染色体畸变试验,均未显示明显的染色体畸变作用。空白和溶剂对照组的染色体无异常,阳性对照组的染色体畸变率为39 % ,显示明显的诱变作用。结果表明昆明山海棠两种提取物在本试验的剂量范围内,对人外周血淋巴细胞染色体无致畸变作用。

关键词: 昆明山海棠, 人淋巴细胞, 染色体畸变

Abstract: This paper reported the effect of Tripterygium hypogiaucum(levl) hutch on chromosome aberration in cultured human peripheral lymphocytes. No substantial positive effect of t riptergium hypogiaucum(levl) hutch ( THH) with 5 doses level (502800μg/ ml) lath agua and alcohol ext ract s(ATH) was shown. It is proved that THH and ATH would not induce mutagenicity in this experiment .

Key words: Triptergium hypoglaucum (levl) Hutch, lymphocytes, Chromosome aberration