癌变·畸变·突变 ›› 2008, Vol. 20 ›› Issue (1): 60-063.doi: 10.3969/j.issn.1004-616x.2008.01.014

• 肿瘤防治 • 上一篇    下一篇

胃癌中RhoC和CD44v6的表达及其临床意义

王　萍1/ 杨金凤1/ 张　庆2/ 承泽农1/ 于东红1   

  1. (1.安徽省感染与免疫重点实验室，蚌埠医学院病理学教研室,安徽　蚌埠　233003；2.蚌埠医学院附属医院中心实验室，安徽　蚌埠　233004)
  • 收稿日期:2007-04-17 修回日期:2007-06-24 出版日期:2008-01-30 发布日期:2008-01-30
  • 通讯作者: 王　萍

Expressions and Clinical Significance of RhoC and CD44v6 in Gastric Carcinoma

WANG Ping1, YANG Jin_feng1, ZHANG Qing2, CHENG Ze_nong1, Yu Dong_hong1   

  1. (1. Anhui Key Laboratory of Infection and Immunology, Department of Pathology，Bengbu Medical College，Bengbu 233003, Anhui; 2. Central Laboratory, Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China)
  • Received:2007-04-17 Revised:2007-06-24 Online:2008-01-30 Published:2008-01-30

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摘要： 背景与目的： 探讨Ras相似蛋白C(Ras homologue C, RhoC)和CD44剪接变异体v6 (CD44 splice variant V6, CD44v6)在胃癌中的表达及其与临床病理因素之间的关系。 材料与方法： 采用免疫组化SP法检测97例胃癌组织中RhoC和CD44v6的表达情况。 结果： 97例胃癌组织中RhoC和CD44v6阳性率分别为77.31％ (75/97)、83.50％ (81/97)，两者表达存在相关性(P<0.05)。RhoC和CD44v6表达均与胃癌的浸润深度和肿瘤分期有关(P<0.05)，且淋巴结转移组RhoC表达显著高于无淋巴结转移组(P<0.05)。 结论： RhoC和CD44v6蛋白的过量表达是胃癌的发生发展中的频发事件，可以作为判断预后的指标之一。

关键词: 胃癌, RhoC, CD44v6, 侵袭, 免疫组化

Abstract: BACKGROUND AND AIM: To investigate the expressions of RhoC and CD44v6 proteins in gastric carcinoma (GC) and their relationship to clinicopathological factors. MATERIALS AND METHODS: Immunohistochemical staining SP method was used to evaluate the expressions of RhoC and CD44v6 in 97 cases of GC. RESULTS: 75(77.31％) and 81(83.50％)of 97 cases showed overexpressions for RhoC and CD44v6, respectively. There was a significant correlation between the overexpression of RhoC and CD44v6 (P<0.05). The expressions of RhoC and CD44v6 in GC were significantly associated with the depth of tumor invasion and TNM staging(P<0.05). Moreover, the RhoC overexpression was associated with lymph node metastasis(P<0.05). CONCLUSION: Overexpressions of RhoC and CD44v6 proteins are frequent events in GC. Measurement of these protein expressions might be used as a prognostic indicator for GC.

Key words: gastric carcinoma, neoplasm, RhoC, CD44v6, invasion, immunohistochemistry

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