姜黄油抗突变作用机理进一步试验研究

doi:10.3969/j.issn.1004-616x.1999.02.004

癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (2): 75-077.doi: 10.3969/j.issn.1004-616x.1999.02.004

姜黄油抗突变作用机理进一步试验研究

赵泽贞　温登瑰　魏丽珍　支惠英　邸海灵1

河北省肿瘤研究所　石家庄　050011 　1河北医科大学第三医院

收稿日期:1998-08-31 修回日期:1998-11-21 出版日期:1999-03-30 发布日期:1999-03-30

A STUDY ON THE MECHANISM OF ANTIMUTAGENESIS OF TURMERIC OIL

Zhao Zezhen1 , Wen Denggui1 , Wei Lizhen1 and Di Hailing2

1Hebei Cancer Instit ute , S hijiaz huang 050011 , 2 The Thi rd Hospital Of Hebei Medical University

Received:1998-08-31 Revised:1998-11-21 Online:1999-03-30 Published:1999-03-30

摘要/Abstract

摘要： 为进一步探讨姜黄油的抗突变作用机理,采用抗突变和致突变同步快速试验法对其做了四种处理方式的试验:A1 姜黄油先与已知致突变剂丝裂霉素C(MMC) 接触,再加入遇到致突变剂即发生突变的指示菌;B1 姜黄油先与上述指示菌接触,用生理盐水(NS) 洗菌,最后加MMC;C1MMC 先与指示菌接触,用NS 洗菌,最后加姜黄油;D1 姜黄油、MMC 和指示菌同时混合接触。以上四种方式在37 ℃下接触20min 后分别做试验。结果A1B1C1D 四种方式的试验结果均显示姜黄油有抗突变效应,提示其既能保护细胞免受损伤又能促使已突变细胞的DNA 修复;既有细胞外直接灭活致突变剂的抗突变作用,又有细胞内的抗突变效应。

关键词: 姜黄油, 抗突变, 机理

Abstract: To understand the mechanism of mutagenesis inhibitory effect of Turmeric oil , the authors designed a series of testing procedures to examine the inhibitory effect by Turmeric oil on the mutagenesis induced by Mitomycine (MMC) in Escherichia Coil lysogenic st rain of GY5027 as indicated by GY4015 as following ways : A.GY5027 was added after Turmeric oil and MMC had been put together for 20 minutes. B. Turmeric oil was added after GY5027 had been t reated with MMC for 20 minutes. C. MMC was added after GY5027 had been treated with Turmeric oil for 20 minutes. D. GY5027 , Turmeric oil and MMC were put into together at the same time. Result s found that in all of the above A , B , C and D experimental designs , the mutagnesis was significantly inhibited by Turmeric oil. This indicates that Turmeric oil might be able to inhibit mutagenesis both intercellularly and ext racellularly and repair genetic damages caused by genotoxicant .

Key words: Turmeric oil, Antimutagenesis, Mechanism

赵泽贞　温登瑰　魏丽珍　支惠英　邸海灵. 姜黄油抗突变作用机理进一步试验研究[J]. 癌变·畸变·突变, 1999, 11(2): 75-077.

Zhao Zezhen , Wen Denggui , Wei Lizhen and Di Hailing. A STUDY ON THE MECHANISM OF ANTIMUTAGENESIS OF TURMERIC OIL[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(2): 75-077.

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姜黄油抗突变作用机理进一步试验研究

A STUDY ON THE MECHANISM OF ANTIMUTAGENESIS OF TURMERIC OIL

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