BRCA1在DNA损伤应激反应中的研究进展

doi:10.3969/j.issn.1004-616x.2016.06.018

癌变·畸变·突变 ›› 2016, Vol. 28 ›› Issue (6): 494-497.doi: 10.3969/j.issn.1004-616x.2016.06.018

• 综述 • 上一篇

BRCA1在DNA损伤应激反应中的研究进展

池林峰¹, 杨军^2,3

1. 浙江中医药大学, 浙江杭州 310053;
2. 浙江大学医学院, 浙江杭州 310058;
3. 杭州师范大学, 浙江杭州 310036

收稿日期:2016-06-17 修回日期:2016-10-11 出版日期:2016-11-30 发布日期:2016-11-30
通讯作者: 杨军,E-mail:gastate@zju.edu.cn E-mail:gastate@zju.edu.cn
作者简介:池林峰,E-mail:linfengchi2014@163.com。
基金资助:
国家自然科学基金（81172692，81373036，81502752）；浙江省自然科学基金（LQ16H220001）

Received:2016-06-17 Revised:2016-10-11 Online:2016-11-30 Published:2016-11-30

摘要/Abstract

摘要： 乳腺癌易感基因BRCA1与乳腺癌、卵巢癌等肿瘤的发生紧密相关。此外，BRCA1还参与了许多重要的细胞信号通路，包括DNA损伤所诱发的细胞应激反应，如DNA损伤导致的细胞周期检验点的激活、DNA损伤修复、染色体重塑及细胞凋亡等。本文对BRCA1在DNA损伤应激反应中的研究进展，尤其是它在DNA双链断裂修复的两种模式（非同源末端连接和同源重组）中的作用作一综述。

关键词: BRCA1, DNA损伤应激反应, 同源重组, 非同源末端连接

中图分类号:

R344+.1

池林峰, 杨军. BRCA1在DNA损伤应激反应中的研究进展[J]. 癌变·畸变·突变, 2016, 28(6): 494-497.

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BRCA1在DNA损伤应激反应中的研究进展

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