关键词: 跨膜4超家族成员1, 肝细胞癌, 复发, 预后

Abstract: OBJECTIVE:To investigate the expression of TM4SF1 and its prognostic value in hepatocellular carcinoma (HCC) patients. METHODS:Immunohistochemistry was performed to determine the expression levels of the TM4SF1 protein in 120 cases of HCC cancerous tissues and their adjacent noncancerous tissues,as well as 30 normal liver tissues from patients without malignant tumors. Associations between TM4SF1 and clinicopathological features as well as prognosis of HCC patients were analyzed. RESULTS:Expression of TM4SF1 in HCC cancerous tissues was significantly higher than noncancerous tissues(P < 0.01). Expression was higher in the high level AFP,lymph node metastasis,PVTT,stages Ⅲ-Ⅳ,poorly differentiated,recurrence,and distant metastasis groups than the low level AFP,without lymph node metastasis,without PVTT,stages Ⅰ-Ⅱ,high differentiated,no recurrence,and no distant metastasis groups (P < 0.05). The high expression levels of TM4SF1 protein were associated with shorter DFS and OS after surgery (P < 0.01). High TM4SF1 level,PVTT,stage Ⅲ-Ⅳ were independent predictors for DFS and OS (P < 0.05). CONCLUSION:TM4SF1 was highly expressed in HCC tissues therefore it may play an important role in HCC carcinogenesis. High TM4SF1 is potentially valuable for prognosis of HCC.

Key words: transmembrane 4 superfamily member1, hepatocellular carcinoma, recurrence, prognosis