主要促进因子超家族成员Mfsd2a的研究进展

doi:10.3969/j.issn.1004-616x.2019.01.017

癌变·畸变·突变 ›› 2019, Vol. 31 ›› Issue (1): 86-88.doi: 10.3969/j.issn.1004-616x.2019.01.017

• 综述 • 上一篇

主要促进因子超家族成员Mfsd2a的研究进展

朱嘉微, 肖汀

国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院, 分子肿瘤学国家重点实验室, 癌发生及预防分子机理北京市重点实验室, 北京 100021

收稿日期:2017-11-23 修回日期:2018-06-19 出版日期:2019-01-31 发布日期:2019-01-31
通讯作者: 肖汀,E-mail:xiaot@cicams.ac.cn E-mail:xiaot@cicams.ac.cn
作者简介:朱嘉微,E-mail:504092093@qq.com。
基金资助:
中国医学科学院医学与健康科技创新项目（2016-I2M-1-001）

Received:2017-11-23 Revised:2018-06-19 Online:2019-01-31 Published:2019-01-31

摘要/Abstract

摘要： 癌症进程是细胞逐步向恶性程度更高、侵袭性更强方向演变的过程，这个过程是由体细胞遗传学和表观遗传学改变的积累引起的。目前研究发现了1个含有遗传组件的106 kb连锁不平衡区域，它与肺腺癌病人生存紧密相关。这个区域精细定位到了1号染色体p34区，包括3个重要的胚胎发育相关基因：MYCL1、TRIT1和Mfsd2a。其中MYCL1和TRIT1在肿瘤生长和发育中所起作用已经相继报道，Mfsd2a被认为是血脑屏障形成和维持完整性的关键组成部分，而对于Mfsd2a在肿瘤中的功能性研究却很少。人类在大脑生长期间如何迅速建立起脂质含量，以及在成年期如何维持其脂质仍未清楚。本文从大脑发育、血脑屏障的维持、疾病的发生等方面介绍主要促进因子超家族成员Mfsd2a在其中发挥的作用。

关键词: 大脑发育, 血脑屏障, 疾病发生, Mfsd2a

中图分类号:

R730.2

朱嘉微, 肖汀. 主要促进因子超家族成员Mfsd2a的研究进展[J]. 癌变·畸变·突变, 2019, 31(1): 86-88.

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主要促进因子超家族成员Mfsd2a的研究进展

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