miRNA调控阿尔茨海默症致病相关基因GSK-3 β表达的研究进展

doi:10.3969/j.issn.1004-616x.2019.04.013

癌变·畸变·突变 ›› 2019, Vol. 31 ›› Issue (4): 331-333.doi: 10.3969/j.issn.1004-616x.2019.04.013

miRNA调控阿尔茨海默症致病相关基因GSK-3 β表达的研究进展

沈杰¹, 郭锡汉¹, 徐伟江¹, 杨国防², 汪旭¹

1. 云南师范大学生命科学学院, 生物能源持续开发与利用教育部工程研究中心, 云南昆明 650500;
2. 上海三誉华夏基因科技有限公司, 上海 201100

收稿日期:2018-11-14 修回日期:2019-03-28 出版日期:2019-07-30 发布日期:2019-08-23
通讯作者: 汪旭,E-mail:wangxu@fudan.edu.cn E-mail:wangxu@fudan.edu.cn
作者简介:沈杰,E-mail:1341154179@qq.com。
基金资助:
国家自然科学基金（31560307，31860301）

Received:2018-11-14 Revised:2019-03-28 Online:2019-07-30 Published:2019-08-23

摘要/Abstract

摘要： 阿尔茨海默症（AD）是一种以进行性痴呆为主要临床表现的中枢神经退行性疾病，是痴呆症中最常见的类型。糖原合成酶激酶-3β（GSK-3β）主要负责微管相关蛋白tau的丝氨酸/苏氨酸的磷酸化。在AD患者脑中GSK-3β的活性增加，使tau过度磷酸化，生成高度磷酸化tau。microRNA是一类长约22 nt、具有重要转录后调控功能的非编码短链RNA。证据表明在AD病理条件下，许多miRNAs参与调节GSK-3β的表达。本文综述了在不同模型中，miRNAs对GSK-3β的转录后调控及后续对AD发生的影响与可能机制。

关键词: 阿尔茨海默症, GSK-3β, miRNA, 转录后调控

中图分类号:

Q291

沈杰, 郭锡汉, 徐伟江, 杨国防, 汪旭. miRNA调控阿尔茨海默症致病相关基因GSK-3 β表达的研究进展[J]. 癌变·畸变·突变, 2019, 31(4): 331-333.

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miRNA调控阿尔茨海默症致病相关基因GSK-3 β表达的研究进展

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