北京市超细颗粒物短期暴露与儿童肺炎发病风险的关联研究

doi:10.3969/j.issn.1004-616x.2025.01.001

癌变·畸变·突变 ›› 2025, Vol. 37 ›› Issue (1): 1-7.doi: 10.3969/j.issn.1004-616x.2025.01.001

• 论著 •

北京市超细颗粒物短期暴露与儿童肺炎发病风险的关联研究

单旭阳¹, 徐洪兵², 徐慧颖¹, 关新朋¹, 方嘉堃¹, 王童³, 徐保平⁴, 张琪⁵, 黄薇¹

1. 北京大学公共卫生学院劳动卫生与环境卫生学系, 北京 100191;
2. 中国医学科学院/北京协和医学院放射医学研究所, 天津 300192;
3. 陆军军医大学军事预防医学系毒理学研究所, 重庆 400038;
4. 首都医科大学附属北京儿童医院, 北京 100045;
5. 中日友好医院, 北京 100029

收稿日期:2024-11-06 修回日期:2024-12-06 发布日期:2025-01-25
通讯作者: 黄薇
作者简介:单旭阳，E-mail：1810306121@pku.edu.cn。
基金资助:
北京市自然科学基金(7222246)

Association between short-term exposure to ultrafine particles and the risk of pneumonia among children in Beijing

SHAN Xuyang¹, XU Hongbing², XU Huiying¹, GUAN Xinpeng¹, Fang Jiakun¹, WANG Tong³, XU Baoping⁴, ZHANG Qi⁵, HUANG Wei¹

1. Department of Occupation and Environmental Health, School of Public Health, Peking University, Beijing 100191;
2. Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192;
3. Institute of Toxicology, College of Preventive Medicine, Army Medical University, Chongqing 400038;
4. Beijing Children's Hospital, Capital Medical University, Beijing 100045;
5. China-Japan Friendship Hospital, Beijing 100029, China

Received:2024-11-06 Revised:2024-12-06 Published:2025-01-25

摘要/Abstract

摘要： 目的：探究超细颗粒物及不同粒径范围颗粒物短期暴露对儿童肺炎发病风险的影响。方法：从首都医科大学附属北京儿童医院、中日友好医院收集2015—2020年0~14岁儿童肺炎急诊数据。通过固定监测站点监测同期空气动力学直径5~560 nm的大气颗粒物数浓度(PNC)以及常规大气污染物浓度。采用时间分层的病例交叉对照研究设计和条件logistic回归模型分析颗粒物短期暴露与儿童肺炎发病风险的关联，并根据年龄、性别、就诊季节进行分层分析。结果： 5~560 nm粒径范围颗粒物短期暴露会导致0~14岁儿童肺炎发病风险上升。粒径5~25、25~100、100~560 nm的颗粒物及超细颗粒物累积滞后0~7 d暴露浓度每升高四分位数间距(IQR)，儿童肺炎发病风险分别上升11.3%[OR=1.113，95%CI(1.063，1.164)]、21.8%[OR=1.218，95%CI(1.159，1.280)]、7.0%[OR=1.070，95%CI(1.037，1.104)]、20.0%[OR=1.200，95%CI(1.143，1.260)]。分层分析结果显示，在冷季超细颗粒物对儿童的肺炎发病风险影响更明显，其累积滞后0~7 d暴露浓度每升高四分位间距，肺炎发病风险上升24.2%[OR=1.242，95%CI(1.178，1.309)]。结论： 5~560 nm粒径大气颗粒物，特别是超细粒径尺度颗粒物短期暴露会增加城市地区儿童肺炎的发病风险。

关键词: 空气污染, 超细颗粒物, 儿童, 肺炎, 发病风险

Abstract: OBJECTIVE： To investigate association between short-term exposure to size-specific ultrafine particles and risk of pediatric pneumonia. METHODS： Data between 2015—2020 were collected on emergency visits for pneumonia in children aged 0~14 years from Beijing Children's Hospital and China-Japan Friendship Hospital. Concurrent monitoring of particle number concentrations (PNC) in size fractions of 5-560 nm，conventional air pollutants，and meteorological data from fixed monitoring stations were collected. A time-stratified case-crossover study design and conditional logistic regression models were used to analyze associations between the exposure and pediatric emergency visits，with stratified analyses by age，gender，and season of visit. RESULTS： The short-term exposures were associated with increased risk of emergency visits for pneumonia in the children. An interquartile range (IQR) increment in PNC_5-25，PNC_25-100，PNC_100-560，and UFP exposure in the cumulative lag 0~7 days was associated with increased risks of emergency visits for pneumonia of 11.3% [OR=1.113，95%CI (1.063，1.164)]，21.8% [OR=1.218，95%CI (1.159，1.280)]，7.0% [OR=1.070，95%CI (1.037，1.104)]，and 20.0% [OR=1.200，95%CI (1.143，1.260)]，respectively. Stratified analysis showed that the effect of ambient particles on risk of the emergency visits was more pronounced during the cold season. For every interquartile range increase in the cumulative lag 0~7 days exposure concentration，the risk of pneumonia emergency visits rises by 24.2% [OR=1.242，95%CI (1.178，1.309)]. CONCLUSION： Short-term exposure to ambient particles in size fractions of 5-560 nm，particularly ultrafine particles，was associated with increased risk of pediatric pneumonia in urban area.

Key words: air pollution, ultrafine particles, children, pneumonia, morbidity risk

中图分类号:

R122

单旭阳, 徐洪兵, 徐慧颖, 关新朋, 方嘉堃, 王童, 徐保平, 张琪, 黄薇. 北京市超细颗粒物短期暴露与儿童肺炎发病风险的关联研究[J]. 癌变·畸变·突变, 2025, 37(1): 1-7.

SHAN Xuyang, XU Hongbing, XU Huiying, GUAN Xinpeng, Fang Jiakun, WANG Tong, XU Baoping, ZHANG Qi, HUANG Wei. Association between short-term exposure to ultrafine particles and the risk of pneumonia among children in Beijing[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2025, 37(1): 1-7.

参考文献

[1] GBD LOWER RESPIRATORY INFECTIONS AND ANTIMICROBIAL RESISTANCE COLLABORATORS. Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic analysis from the global burden of disease study 2021[J]. Lancet Infect Dis, 2024, 24(9): 974-1002.
[2] GBD DISEASES AND INJURIES COLLABORATORS. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of disease study 2021[J]. Lancet, 2024, 403(10440): 2133-2161.
[3] LIN L Z, CHEN J H, YU Y J, et al. Ambient air pollution and infant health: a narrative review[J]. EBioMedicine, 2023, 93: 104609.
[4] MARANGU D, ZAR H J. Childhood pneumonia in low-and-middle-income countries: an update[J]. Paediatr Respir Rev, 2019, 32: 3-9.
[5] JIANG Y, ZHAO Y F, WANG Q L, et al. Fine particulate matter exposure promotes M2 macrophage polarization through inhibiting histone deacetylase 2 in the pathogenesis of chronic obstructive pulmonary disease[J]. Ann Transl Med, 2020, 8(20): 1303.
[6] LU X, LI R Q, YAN X X. Airway hyperresponsiveness development and the toxicity of PM2.5[J]. Environ Sci Pollut Res Int, 2021, 28(6): 6374-6391.
[7] ZHAO Q, KRESS S, MARKEVYCH I, et al. Air pollution during infancy and lung function development into adolescence: the GINIplus/LISA birth cohorts study[J]. Environ Int, 2021, 146: 106195.
[8] GEHRING U, GRUZIEVA O, AGIUS R M, et al. Air pollution exposure and lung function in children: the ESCAPE project[J]. Environ Health Perspect, 2013, 121(11/12): 1357-1364.
[9] BEENTJES D, SHEARS R K, FRENCH N, et al. Mechanistic insights into the impact of air pollution on pneumococcal pathogenesis and transmission[J]. Am J Respir Crit Care Med, 2022, 206(9): 1070-1080.
[10] NAKHJIRGAN P, KASHANI H, KERMANI M. Exposure to outdoor particulate matter and risk of respiratory diseases: a systematic review and meta-analysis[J]. Environ Geochem Health, 2023, 46(1): 20.
[11] YEE J, CHO Y A, YOO H J, et al. Short-term exposure to air pollution and hospital admission for pneumonia: a systematic review and meta-analysis[J]. Environ Health, 2021, 20(1): 6.
[12] FANG J K, SONG X M, XU H B, et al. Associations of ultrafine and fine particles with childhood emergency room visits for respiratory diseases in a megacity[J]. Thorax, 2022, 77(4): 391-397.
[13] LEITTE A M, SCHLINK U, HERBARTH O, et al. Size-segregated particle number concentrations and respiratory emergency room visits in Beijing, China[J]. Environ Health Perspect, 2011, 119(4): 508-513.
[14] KULMALA M, VEHKAM-KI H, PET-J-T, et al. Formation and growth rates of ultrafine atmospheric particles: a review of observations[J]. J Aerosol Sci, 2004, 35(2): 143-176.
[15] JERRETT M. Air pollution as a risk for death from infectious respiratory disease[J]. Am J Respir Crit Care Med, 2022, 205(12): 1374-1375.
[16] ZHENG J Y, YANG X, HU S Q, et al. Association between short-term exposure to air pollution and respiratory diseases among children in China: a systematic review and meta-analysis[J]. Int J Environ Health Res, 2022, 32(11): 2512-2532.
[17] LI H J, LIU L J, CHEN R J, et al. Size-segregated particle number concentrations and outpatient-department visits for pediatric respiratory diseases in Shanghai, China[J]. Ecotoxicol Environ Saf, 2022, 243: 113998.
[18] LI Y, ZHU T, ZHAO J C, et al. Interactive enhancements of ascorbic acid and iron in hydroxyl radical generation in quinone redox cycling[J]. Environ Sci Technol, 2012, 46(18): 10302-10309.
[19] GUO L L, SALIMI F, WANG H, et al. Experimentally determined deposition of ambient urban ultrafine particles in the respiratory tract of children[J]. Environ Int, 2020, 145: 106094.
[20] TRABOULSI H, GUERRINA N, IU M, et al. Inhaled pollutants: the molecular scene behind respiratory and systemic diseases associated with ultrafine particulate matter[J]. Int J Mol Sci, 2017, 18(2): 243.
[21] MA Y L, YUE L, LIU J T, et al. Association of air pollution with outpatient visits for respiratory diseases of children in an ex-heavily polluted Northwestern city, China[J]. BMC Public Health, 2020, 20(1): 816.
[22] SIGMUND E, DE STE CROIX M, MIKLáNKOVá L, et al. Physical activity patterns of kindergarten children in comparison to teenagers and young adults[J]. Eur J Public Health, 2007, 17(6): 646-651.
[23] YAN R, YING S J, JIANG Y X, et al. Associations between ultrafine particle pollution and daily outpatient visits for respiratory diseases in Shanghai, China: a time-series analysis[J]. Environ Sci Pollut Res Int, 2024, 31(2): 3004-3013.
[24] BECKLAKE M R, KAUFFMANN F. Gender differences in airway behaviour over the human life span[J]. Thorax, 1999, 54(12): 1119-1138.
[25] LI H J, LI X L, ZHENG H M, et al. Ultrafine particulate air pollution and pediatric emergency-department visits for main respiratory diseases in Shanghai, China[J]. Sci Total Environ, 2021, 775: 145777.
[26] CHEN P C, MOU C H, CHEN C W, et al. Roles of ambient temperature and PM2.5 on childhood acute bronchitis and bronchiolitis from viral infection[J]. Viruses, 2022, 14(9): 1932.
[27] MORIYAMA M, HUGENTOBLER W J, IWASAKI A. Seasonality of respiratory viral infections[J]. Annu Rev Virol, 2020, 7(1): 83-101.
[28] XU H B, SONG J, HE X H, et al. Ambient anthropogenic carbons and pediatric respiratory infections: a case-crossover analysis in the megacity Beijing[J]. Geohealth, 2023, 7(8): e2023GH000820.

北京市超细颗粒物短期暴露与儿童肺炎发病风险的关联研究

Association between short-term exposure to ultrafine particles and the risk of pneumonia among children in Beijing

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