癌变·畸变·突变 ›› 2010, Vol. 22 ›› Issue (4): 302-304.doi: 10.3969/j.issn.1004-616x.2010.04.013

• 检测研究 • 上一篇    下一篇

纳米二氧化钛和纳米氧化锌的Ames试验

马茂才1;黄萍1;晏辉2;陶云1;邓雅斌 1;李东辉1   

  1. 1. 厦门大学医学院抗癌研究中心, 福建 厦门 361005; 2.广州市海珠区人民医院,广东 广州 510220
  • 收稿日期:2010-01-25 修回日期:2010-04-21 出版日期:2010-07-30 发布日期:2010-07-30
  • 通讯作者: 李东辉

Ames test of nano TiO2 and nano ZnO

MA Mao-cai1;HUANG Ping1;YAN Hui2;TAO Yun1;DENG Ya-bin1;LI Dong-Hui1   

  1. 1.Cancer Research Center, Medical College, Xiamen University, Xiamen 361005; 2. People's Hospital of Haizhu, Guangzhou 510220, Guangdong, China
  • Received:2010-01-25 Revised:2010-04-21 Online:2010-07-30 Published:2010-07-30
  • Contact: LI Dong-hui

摘要: 目的: 研究纳米二氧化钛、纳米氧化锌两种纳米光催化材料的潜在致突变性。 方法: 采用Ames 试验平板掺入法,计数TA97,TA98,TA100,TA102四种菌株分别在纳米二氧化钛及纳米氧化锌5个不同浓度下的回变菌落数。 结果: 纳米二氧化钛、纳米氧化锌材料各剂量组均未引起测试菌株回变菌落数的明显增加。Ames试验结果均为阴性。 结论: 纳米二氧化钛、纳米氧化锌在实验剂量范围内未见致突变性。

关键词: 纳米光催化材料, Ames试验, 致突变性, 纳米二氧化钛, 纳米氧化锌

Abstract: OBJECTIVE: To study the potential mutagenicity of two photocatalytic nanomaterials, nano TiO2 and nano ZnO. METHODS: In the plate incorporation test of Salmonella typhimurium, the average colony number of spontaneous revertants of TA97, TA98, TA100, TA102 were set at 5 concentrations. RESULTS: The colony number of revertants for the materials tested did not increase with statistical significance, compared with that of spontaneous revertants. The results of Ames test for the two kinds of nanoparticle were negative. CONCLUSION: The results imply that the two kinds photocatalytic nanomaterials tested did not show potential mutagenicity.

Key words: photocatalytic nanomaterials, Ames test, mutagenicity, nano titanium dioxide, nano zinc oxide

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