关键词: 前庭损伤, 庆大霉素, 小鼠, 模型, 接触翻正反射, 头偏

Abstract: BACKGROUND＆AIM: To establish a convenient and feasible animal model of vestibular dysfunction in mice. MATERIAL AND METHODS： A dose of 400 mg gentamicin /(kg·d) was given to mice subcutaneously twice daily for 15 consecutive days. Vestibular function was assessed by contact righting reflex as well as the head tilt and swimming behavior, and histopathology of the animals' saccular and utricular macula or crista ampullaris was examined. RESULTS：Time of contact righting reflex was prolonged, scores of head tilt and swimming behavior were higher than control. Meanwhile, damage of saccular and utricular macula or crista ampullaris of mice were confirmed by histopathological examination. CONCLUSION： This is a convenient and feasible model of experimental vestibular dysfunction in small animals for research on pharmacodynamics of prophylactic drugs for motion sickness and vertigo.

Key words: vestibular dysfunction, gentamicin, mice, model, contact righting reflex, head tilt