癌变·畸变·突变 ›› 2003, Vol. 15 ›› Issue (1): 17-20.doi: 10.3969/j.issn.1004-616x.2003.01.005

• 论著 • 上一篇    下一篇

hTRT和C-myc的表达在食管上皮增生和癌变过程中的意义

吴名耀1, 吴贤英1, 庄楚香2   

  1. 1. 汕头大学医学院病理教研室; 2. 汕头大学医学院生理教研室, 广东 汕头 515031
  • 收稿日期:2002-07-10 修回日期:2002-09-10 出版日期:2003-01-30 发布日期:2003-01-30
  • 通讯作者: 吴名耀

THE SIGNIFICANCE OF EXPRESSION OF hTRT AND C-myc IN ESOPHAGEAL EPITHELIOSIS AND CARCINOGENESIS

WU Ming-yao 1, WU Xian-ying 1, ZHUANG Chu-xiang 2   

  1. Department of Pathology, 2. Department of Physiology, Shantou University Medical College, Shantou, 515031 , China
  • Received:2002-07-10 Revised:2002-09-10 Online:2003-01-30 Published:2003-01-30
  • Contact: WU Ming-yao

摘要: 目的: 研究食管粘膜上皮癌变过程人端粒酶反转录酶(hTRT)和C-myc蛋白的表达,并探讨其与食管癌发生的关系。 方法: 应用免疫组化S-P法,观察70例食管癌切除新鲜标本的上切缘正常粘膜、癌旁食管粘膜上皮和食管原位癌组织中hTRT和C-myc蛋白的表达情况。 结果: hTRT和C-myc在增生和恶变的食管粘膜上皮细胞表达,两者在食管癌变过程显示相同的分布模式。 结论: 端粒酶hTRT和C-myc蛋白的表达与食管粘膜上皮的恶性转化密切相关,端粒酶hTRT的重新激活和C-myc的上调表达可能在食管癌的组织发生中起关键性作用。

关键词: hTRT, C-myc, 食管上皮, 癌变

Abstract: Purpose: To investigate the expression of human telomerase reverse transcriptase (hTRT) and C-myc in esophageal epitheliosis and carconogenesis, and their relation to the development of esophageal carcinoma. Methods: Telomerase hTRT and C-myc protein expression in 70 fresh tissue specimen, including esophageal mucosa above the upper surgical margin, carcinoma in situ and mucosa adjacent to tumor, were detected using immunohistochemical method. Results: hTRT and C-myc protein were expressed in proliferating and transformed malignant cells of esophageal epithelium. The expression of C-myc protein showed a similar distribution pattern to that of hTRT. Conclusion: Telomerase hTRT and C-myc protein expressions are closely related to the malignant transformation of esophageal epithelium. The reactivated telomerase and up-regulated C-myc may play a crucial role in the development of esophageal carcinoma.

Key words: hTRT, C-myc, Esophageal epithelium, Carcinogenesis