癌变·畸变·突变 ›› 2008, Vol. 20 ›› Issue (6): 481-482.doi: 10.3969/j.issn.1004-616x.2008.06.017

• 论著 • 上一篇    下一篇

白头翁水提物的抗诱变和抗氧化作用的初步研究

刘忠平1, 庞会民2, 赵云霄3, 朱玉琢2   

  1. 1.吉林医药学院组织胚胎学教研室,吉林 吉林132013;2.吉林大学基础医学院医学遗传学教研室,吉林 长春 130021;3.长春急救中心,吉林 长春 130062
  • 收稿日期:2008-03-03 修回日期:2008-05-06 出版日期:2008-11-30 发布日期:2008-11-30

Preliminary Study on Antimutag-enesis and Antioxidation of Aqueous Extract of Pulsatilla Chinensis Regel

LIU Zhong-ping1, PANG Hui-min2,ZHAO Yun-xiao3,ZHU Yu-zhuo2,   

  1. 1.Deparment of Histology and Embryology,Jilin Medical College,Jilin 132013,Jilin; 2.Department of Medical Genetics,Jilin University, Changchun 130021,Jilin; 3.Emergency Centre,Changchun 130062,Jilin, China
  • Received:2008-03-03 Revised:2008-05-06 Online:2008-11-30 Published:2008-11-30

摘要: 背景与目的: 观察白头翁水提物(PWE)的抗诱变和抗氧化作用。 材料与方法: 以环磷酰胺(CP)为诱变剂,检测PWE对小鼠骨髓嗜多染红细胞(PCE)微核(MN)率的影响,并以维生素C(Vit C)为抗氧化对照剂,检测PWE对小鼠血清超氧化物歧化酶(SOD)活性和血清总抗氧化能力(T-AOC)的影响。 结果: 白头翁水提物能显著降低环磷酰胺所诱发的微核率、提高小鼠血清超氧化物歧化酶活性、增强总抗氧化能力,与阳性对照组(CP)比较,差异均具有统计学意义(P<0.05)。 结论: 白头翁水提物具有抗诱变和抗氧化作用。其机制可能与消除自由基、中断或终止自由基的氧化反应,增强机体的总抗氧化能力有关。

关键词: 白头翁, 环磷酰胺, 抗诱变, 抗氧化

Abstract: BACKGROUND AND AIM:To study the antimutagenesis and antioxidation properties of aqueous extract of Pulsatilla Chinensis Regel. MATERIALS AND METHODS: Tested the micronucleus rate of bone marrow PCE cell in mice, serum superoxide dismutase(SOD)activity and total anti-oxidative abilities(T-AOC)in mice serum by CP as mutagen and Vit C as control of antioxidant. RESULTS: The aqueous extract of Pulsatilla Chinensis Regel reduced the micronucleus rate of bone marrow PCE cell in mice,and increased SOD activity and T-AOC in mice serum. CONCLUSION: The aqueous extract of Pulsatilla Chinensis Regel showed antimutagenesis and antioxidation activities.The mechanism may lie in eliminating free radicals,interrupting and terminating oxidizing reaction of free radicals,and enhancing the overall anti-oxidative abilitiy.

Key words: pulsatilla chinensis regel, cyclophosphamide, antimutagenesis, antioxidation