Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (1): 15-018.doi: 10.3969/j.issn.1004-616x.1998.01.006

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EFFECTS OF SODIUM SELENITE AND RETINOIC ACID ON MNNG - INDUCED UNSCHEDULED DNA SYNTHESIS OF HUMAN WHOLEBLOOD CELLS

Cao J ie1 ,Li Ruizhen2 ,Shi Yongliang2 ,Wu Duanzong2 ,Gong Shuming2   

  1. 1Department of heal th toxicology , the Second Military Medical University , S hanghai 200433
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

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Abstract: The effect s of sodium selenite (Na2SeO3) retinoic acid (RA) and Na2SeO3 + RA were examined on MNN G - induced DNA damaged with human wholeblood cells by the test of unscheduled DNA synthesis (UDS) in vit ro. The result s showed that 0. 01～0. 05μg/ ml Na2SeO3and 0. 02～2. 0μg/ ml RA significantly suppressed the responses of UDS induced by MNN G.These revealed that Na2SeO3 and RA had the antimutagenic activity. The combined inhibiting effect of (0. 1μg/ ml) Na2SeO3 + (0. 1μg/ ml) RA on MNN G- induced DNA damage was st ronger than the simply effect of Na2SeO3 . The result s also revealed that Na2SeO3 ,as inhibitor of mutagenesis ,could induce genetoxic effect s by it self at higher dose levels.

Key words: sodium selenite, retinoic acid, antimutagenesis, chemoprevention