Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (2): 98-101.doi: 10.3969/j.issn.1004-616x.1998.02.009

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STUDY ON THE INHIBITION OF CYT P450 CONTENT AND EROD ACTIVITY OF LIVER MICROSOMAL PREPARATION BY ORGANOAERMANIUM COMPOUNDS ( G- 132) IN RATS

Xia Qinglin , Mo ziyao , Du Yanyan , Mai Huixia   

  1. Antiepidemic station of GuangZhou , GuangZhou 　510080
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-03-30 Published:1998-03-30

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Abstract: Male SD rat s were fed orally with Ge - 132 100 , 250 and 500mg/ kg each day for 25days , Cyt P450 of liver cell of high dose group was inhibited significantly ( P < 0. 05) , EROD activity was also inhibited about 50 percent in the group compared with the cont rol. The animals were pret reated with Ge - 132 500mg/ kg/ d for 20 days , then give PB and 3 - MC , found that the inhibition of P450 induced by PB was not obvious , but there was 33 percent inhibition of EROD activity induced by 3 - MC.

Key words: Organogermaninm Compounds ( Ge - 132), P450, EROD activity, Inhibition