对苯二酚诱发果蝇生殖细胞非整倍体的研究

doi:10.3969/j.issn.1004-616x.1998.03.004

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (3): 141-144.doi: 10.3969/j.issn.1004-616x.1998.03.004

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ANEUPLOID INDUCTION BY HYDROQUINONE IN GERM CELLS OF DROSOPHILA MELANOGASTER

He Zheng Ji , Wang Xu , Liu Su Qing

Department of Life Sciences , Yunnan Normal University , Kunming 　650092

Received:1900-01-01 Revised:1900-01-01 Online:1998-05-30 Published:1998-05-30

Abstract

Abstract: The Oregon K system of Drosophila melanogaster was employed for the detection of germ cell aneuploid induced by hydroquinone (HQ) and colchicine (COL) . Adult flies were treated by feeding the chemicals. HQ at doses 12218mg/ ml and COL (2. 5 - 20μg/ ml) significantly induced the exceptional off spring (XXY, XO) derived f rom aneuploidy germ cells. It was showed than COL had much higher efficiency on aneuploid induction than HQ and shared a strong effect on chromosome lossing in treated parental males. No significant sex differences among HQ t reated animals for the chromosome lossing and mal2segregation in germ cell development were found.The experiment indicated that HQ and COL are aneugens in Drosophila germ cells.

Key words: Hydroquinone, Drosophila melanogaster, Nondisjunction, Chromosome loss, Aneuploidy

He Zheng Ji , Wang Xu , Liu Su Qing. ANEUPLOID INDUCTION BY HYDROQUINONE IN GERM CELLS OF DROSOPHILA MELANOGASTER[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(3): 141-144.

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ANEUPLOID INDUCTION BY HYDROQUINONE IN GERM CELLS OF DROSOPHILA MELANOGASTER

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