Abstract: To study the relationship between sex hormone receptors and lung tumor ,est rogen receptor ( ER) and progesterone receptor ( PR) were detected by immunohistochemical technique in mice lung tumors induced by urethane and diethylstilbest rol. The f requency of presence of ER and PR in malignant tumor were both higher than which were induced by urethane alone. Presence of ER correlated significantly with size of malignant tumors ,but not with size of benign tumors. PR did not correlate with size of both benign and malignant tumors. The ER and PR positive rates (46. 3 % and 52. 5 % respectively) of malignant tumors were significantly higher than those of benign tumors(18. 8 % and 20. 2 % respectively) . The positive rate for both ER and PR were 11.6 % in benign tumors and 31. 3 % in malignant tumors ,the negative rate were 72. 5 % and 32. 5 % respectively. The result suggested the est rogen dependency of lung tumor ,and also might be helpful for clinical endocrine therapy of lung cancer.

Key words: est rogen receptor, progesterone receptor, lung tumor