Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (6): 355-358.doi: 10.3969/j.issn.1004-616x.1998.06.007

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CYTOCHROME P450 2E1 GENETIC POLYMORPHISM AND NON- SMOKING FEMALE LUNG CANCER RISK

Qu Yonghua , et al   

  1. S hanghai Cancer Instit ute , S hanghai 　200032
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-11-30 Published:1998-11-30

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Abstract: The blood of 100 non - smoking female lung cancer cases and 95 healthy cant rols82cases and 89 cont rols were collected from Shanghai and Harbin population respectively. The DNA were ext racted from buffy coat with phenol2chloroform. Cytochrome P450 (CYP) 2E1 genotype were analyzed with rest riction enzyme Dra I for the sixth int ron and Rsa I for the 5’2flanking region. The OR reach 2. 56 and 5. 47 for CYP2E1 Dra I and Rsa I homozygous mutant respectively in Shanghai cases , but there were no statistic significance. Though in Harbin cases the OR reach 0. 49 and 0. 47 , also no significance.

Key words: Non2smokng lung cancer, CYP2E1, Genotype