Abstract: The genetic toxicity of tet randrine on mice was studied by sperm deformity test ,marrow micronucleus test and sister chromatid exchange. The results showed that the rate of spermatic deformity and marrow cells micronucleus in mouse was increased significantly in growps t reated with tet randrine , and there was dose-response relationship , but the change of the f requencies of sister chromatid exchanges was not obvious. It is concluded that tet randrine has genetic toxicity to experimental animal.

Key words: tet randrine, microncleus, sister chromatid exchange, sperm diformity