rhEPO 注射液致突变作用研究

doi:10.3969/j.issn.1004-616x.1999.05.026

Abstract

Abstract: Three batches of rhEPO injections were studied on mutagenicity by Ames test and micronucleus test of PCE in mouse bone marrow. The Ames test result s showed that the reversion mutation f requencies of three batches of rhEPO injections with five doses ( 18. 75～300. 00 IU/ plate) didn’t increase in st rain TA97 , TA98 ,TA100 and TA102 with or without S9mix ; In 15000～60000 IU/ kg doses , the f requencies of micronucleus in bone marrow PCE cells of mice didn’tincrease. It showed three batches of rhEPO injections had no mutagenicity.

Key words: rhEPO Injections, Ames test, micronuclues test of PCE in mouse bone marrow, mutagenicity

Hu Yanping , Li Yanhong. THE STUDY ON MUTAGENICITY OF rhEPO INJECTIONS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(5): 275-276.

[1]	SHI Wenjing, ZHANG Jiqianzhu, ZHU Jiangbo, ZHANG Xiaofang, WANG Ruina, DAI Xiaoyu, REN Lijun, TIAN Yijun. Evaluation of genotoxicity of diphenhydramine hydrochloride and caffeine compound [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 149-153,157.
[2]	GE Xianmin, LI Bin, HUANG Chaopei, GAO Yuqiu, LUO Hailan, YANG Hui, WANG Yanwu, WEN Pingjing, LAN Guanghua, CHEN Huanhuan, MENG Qin, LUO Liuhong, DENG Yueqin, LIU Shuaifeng, WU Xiuling. Acute oral toxicity and mutagenicity of combined drugs for anti HIV [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 466-469,474.
[3]	HUANG Chaopei, QIN Huiyan, ZHANG Lujuan, WANG Yanwu, HE Li, FU Weizhong. Study on acute toxicity and mutagenicity of Aronia melanocarpa extract in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 474-476.
[4]	ZHOU Su, LI Rui, ZHU Hongyan, ZHANG Zhichao, FANG Jing, TANG Liming. An optical density method for determining bacterial concentrations in the Salmonella typhimurium reverse mutation assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 62-66.
[5]	ZHENG Kai, WANG Bingyu, XU Xinyun, GENG Hong, HUANG Haiyan, LIU Wei, LONG Dingxin. Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 483-487.
[6]	CAO Yiyi, XI Jing, TANG Weifeng, YOU Xinyue, LIU Weiying, LUAN Yang. Genotoxicity evaluation of triclosan in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 71-75.
[7]	JIANG Yi, JIA Xiaohui, LI Peining, CHEN Xiujuan, LIU Donghong, LIU Xiangmei. Ames mutagenicity assay on five plastic surface chemicals in racetrack [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 309-312.
[8]	YUAN Ye, CHEN Dandan, JING Shufang, YU Yongsheng, CHEN Jianheng, WU Chunqi, SHI Chang. Mutagenic effects of N-(n-butyl)-thiophosphorictriamide in somatic and germ cells of mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(6): 432-437.
[9]	SHAN Chun, HU Peili, ZHANG Luyong, LIU Ting, LIN Fei. Different induction and cryopreservation methods on metabolic activities of rat liver S9 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 388-392.
[10]	CAO Yiyi, LIU Qian, XI Jing, MA Leilei, LIU Xiaojian, LUAN Yang. Comparative evaluation of mutagenicity of four aristolochic acids components using the Ames fluctuation test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 398-402.
[11]	GAO Mei, CAO Chong, YING Yong, MA Hui, JIA Qingwen. Comparison of different inductionmethods on activity of rat liver microsomal enzymes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 269-272.
[12]	YING Jian, HAO Binxiu, MENG Qingjia, CHEN Ran, WANG Liming, WANG Chunling. Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 306-309,324.
[13]	LUO Xueting, CAI Qijun, ZHAO Bo, CHEN Weimin, CHEN Xiao, ZHANG Xiaowen. Evaluation of acute and genetic toxicity of Zihe herbal solid beverage in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 302-305.
[14]	TANG Jiao, ZHAO Min, YANG Ying, LI Qing, HUANG Junming, YANG Xingfen. Study on acute toxicity and mutagenicity of Panaxnotoginseng [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 66-68,72.
[15]	YAN Jiuming, YUE Qianlan, JIA Zhenchao, LI Yan, ZHANG Lishi. General toxicity and mutagenic effects of Mulberry-Astragalus capsule [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(6): 472-476.

THE STUDY ON MUTAGENICITY OF rhEPO INJECTIONS

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments