Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (2): 79-081.doi: 10.3969/j.issn.1004-616x.2000.02.005

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STUDY ON THE GROWTH INHIBITION OF VITAMIN E SUCCINATE IN HUMAN GASTRIC CANCER CELL

LIU Bai-he , WU Kun   

  1. Public Heal th College of Harbin Medical University , Harbin  150001 , China
  • Received:1999-04-29 Revised:1999-10-03 Online:2000-04-30 Published:2000-04-30

Abstract: Purpose and Methods : This paper observed the effect s of Vitamin E Succinate (VES) on cell growth ,DNA synthesis and the appearance of apoptosic morphological change in human gast ric cancer SGC - 7901 cell line in vit ro. Results : The result s showed that VES (5μg/ ml 、10μg/ ml and 20μg/ ml) could obviously inhibit SGC27901 cell growth and DNA synthesis in a dose-dependent manner , and induce apoptosis of SGC27901 cell.Conclusion : These result s indicate that the inhibition of VES on SGC27901 cell growth was by the way of inhibiting cellular DNA synthesis and inducing apoptosis.

Key words: Vitamin E Succinate, human gast ric cancer SGC-7901 cell, t ritium thymidine incorporation, apoptosis

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