昆明山海棠对人精子染色体的诱变作用研究

doi:10.3969/j.issn.1004-616x.2000.02.009

Abstract

Abstract: Purpose and Methods : The effects of Tripterygiu hypoglaucum(Level) hutch ( THH) on the induction of chromosome abnormalities in human spermatozoa were studied using the human sperm chromosome assay.Results : Result s showed the rates of chromosome aberrations of THH at the doses 50μg/ ml , 100μg/ ml , 200μg/ml were 11. 54 % , 15. 71 % , 16. 79 % respectively , while 7. 25 % in cont rol group. There were significant differences 100μg/ ml group and 200μg/ ml group as compared with cont rol group ( P < 0. 05) . The mean value of chromosome breakages of 100μg/ ml , 200μg/ ml and cont rol groups were 0. 2143 , 0. 2214 and 0. 1346 respectively , the difference was significant ( P < 0. 05) , when the two tested groups compared with the cont rol group.Conclusion : The study result s showed that THH was clastogen in human spermatozoa chromosome aberration test .

Key words: Tripterygium hypoglaucu(Level) Hutch, Spermatozoa, Chromosome, Mutagenicity

CLC Number:

R394
Q343113

MA Ming - fu , CAI Min , L I Lian - bing , ZEN G Wei - san , L I Xin - sheng. EFFECTS OF TRIPTERYGIUM HYPOGLAUCUM ( LEVEL) HUTCH ON THE CHROMOSOME IN HUMAN SPERMATOZOA IN VITRO[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(2): 90-092.

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EFFECTS OF TRIPTERYGIUM HYPOGLAUCUM ( LEVEL) HUTCH ON THE CHROMOSOME IN HUMAN SPERMATOZOA IN VITRO

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