乙酰胆碱受体抑制剂对猪脑微管蛋白聚合的影响

doi:10.3969/j.issn.1004-616x.2001.02.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (2): 70-073.doi: 10.3969/j.issn.1004-616x.2001.02.002

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A STUDY ON PORCINE TUBULIN POLYMERIZATION IN VI TRO AFFECTED BY TWO KINDS OF ANTAGONISTS OF CHOLINERGIC RECEPTORS

SONG Zhong-kui, LIANG Zi-qing, WANG Xu

School of Life Sciences, Yunnan Normal University, Kunming Yunnan 650092, China

Received:2000-08-20 Revised:2000-10-18 Online:2001-04-30 Published:2001-04-30

Abstract

Abstract: Purpose : Two kinds of antagonist s to cholinergic receptors , at ropine sulfate and d2tubocurarine , were analyzed for their effect s on porcine tubulin polymerization. Methods : Two chemicals were added into the tubulin polymerization/ depolymerization system and the changes of absorption values at value decreased significantly at the reaction solution. The results indicated that 350 nm and 37 ℃were recorded. Results : The chemicals made the absorption value decreased significantly at the reaction solution. The result s indicated that the chemicals st rongly inhibit the polymerization of tubulin. Conclusion : The tested chemicals interrupt the mitosis by tubulin polymerization and may induce aneuploidy by the pathway.

Key words: at ropine, d2tubocurarine, tubulin polymerization, aneuploidy

CLC Number:

R99. 4

SONG Zhong-kui, LIANG Zi-qing, WANG Xu. A STUDY ON PORCINE TUBULIN POLYMERIZATION IN VI TRO AFFECTED BY TWO KINDS OF ANTAGONISTS OF CHOLINERGIC RECEPTORS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(2): 70-073.

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A STUDY ON PORCINE TUBULIN POLYMERIZATION IN VI TRO AFFECTED BY TWO KINDS OF ANTAGONISTS OF CHOLINERGIC RECEPTORS

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