Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (3): 157-160.doi: 10.3969/j.issn.1004-616x.2003.03.009

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STUDY ON ACUTE TOXICITY AND MUTAGENTICITY OF POLYOXOANIONS α-K 8H 2 [SiW 9Ti 3O 40]•15H 2O

MEI Shu-jiang,LIU Ya,WANG Bao- Gui，et al   

  1. 1.Department of biiology,Shantou University Medical College,Shantou 515031,China;2.College o f Preventive Medicine,Jilin University,Changchun 130021,China;3.Health Supervision Office of Changchun Health Bureau Changchun 130021，China
  • Received:2003-04-20 Revised:2003-05-15 Online:2003-07-30 Published:2003-07-30
  • Contact: MEI Shu-jiang

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Abstract: Purpose: To study the oral acute toxicity and mutagenicity of Polyoxometalates α-K8H2[SiW9Ti3O40]•15H2O for clinic application(α-Ti3). Methods: The studies were conducted with acute toxicity test,Ames test,micronuclei test and chromosome aberration test on CHO cell in vitro. Results: ① LD50 in mice was 2 055.36 mg/kg ,it was a low-grade toxicity compound .②The results of Ames test showed no mutagenic effects with the concentration ranged from 31.3 to 500 μg/plate with or without S9 mixture added. ③In micronuclei test,the mice orally received 25,50,125 mg/kg level of α-Ti3,no mutagenic effects were observed,and no significant increase was observed on polychromatophil.④The chromosome aberration ratio of α-Ti3 was no significant discrepancy compared with the control on CHO cells,with the concentration ranged from 40 to 320 μg /ml with or without S 9 mixture added. Conclusion： The toxicity of α-Ti 3 was low and no mutagenicity was observed in the experiment.

Key words: Polyoxometalates, α-K8 H2 [SiW9Ti3 O 40]•, 15H2 O, LD50, Ames test, micronuclei, chromosome aberration