Abstract: Purpose： To observe antagonistic effects of garlic extract(GE)and vitamin E to mutagenicity of condensates of cooking oil fumes(COF). Methods： SCE(sister chromatid exchange) was observed and compared before and after addition of garlic extract or vitamin E in different amounts to the culture of human peripheral blood lymphocytes containing different amounts of COF. Then GE(1:10 000 dilution)and / or vitamin E (5 μl) were added to the culture of human peripheral blood lymphocytes containing COF 10μl to compare the changes in SCE. Results： Garlic extract(1:10 000 dilution) could lower SCE of lymphocytes(P< 0.05); Garlic extract and vitamin E had a very significantly synergistic effect on lowering SCE of lymphocytes treated by COF(P< 0.01). Conclusions： Garlic extract and vitamin E have a synergistic effect to antagonize the mutagenicity of COF; garlic extract alone can also lower SCE of human peripheral blood lymphocytes.

Key words: garlic, vitamin E, condensates of cooking oil fumes, cooperativity