鳞癌与基底细胞癌的Fas/FasL表达及其与细胞凋亡的关系

doi:10.3969/j.issn.1004-616x.2003.04.008

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 215-216.doi: 10.3969/j.issn.1004-616x.2003.04.008

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THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA,BASAL CELL CARCINOMA AND CELL APOPTOSIS

YANG Kai-yan1,YU Kang2,LI Jian-min1,et al

1.Department of Pathology The First Hospital of Wenzhou Medical College , Wenzhou 325000, China. 2. Deaertment of Hematology The First A ffiliated Hospital of Wenzhou Medical College , Wenzhou 325000, China

Received:2003-02-06 Revised:2003-04-30 Online:2003-10-30 Published:2003-10-30
Contact: YANG Kai-yan

Abstract

Abstract: Purpose: To explore the relationship between Fas/FasL expression in squamous cell carcinoma, basal cell carcinoma or cell apoptosi. Methods: Fas/FasL expression and cell apoptosis were studied in 45 patients suffering from squamous cell carcinoma or basal cell carcinoma by immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP-DIG nick end labeling (TUNEL). Results: Fas/FasL expression in squamous cell carcinoma was higher than in basal cell carcinoma. The apoptosis rate of Fas/FasL positive cells was higher than that of Fas/FasL negative cells. Conclusion: Fas/FasL system was rather associated with cell apoptosis and may play an important role in tumor invasion.

Key words: squamous cell carcinoma, basal cell carcinoma, apoptosis, Fas/FasL

YANG Kai-yan, YU Kang, LI Jian-min, et al. THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA,BASAL CELL CARCINOMA AND CELL APOPTOSIS[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(4): 215-216.

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THE RELATIONSHIP BETWEEN Fas/FasL EXPRESSION IN SQUAMOUS CELL CARCINOMA,BASAL CELL CARCINOMA AND CELL APOPTOSIS

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