Carcinogenesis, Teratogenesis & Mutagenesis ›› 2003, Vol. 15 ›› Issue (4): 220-222.doi: 10.3969/j.issn.1004-616x.2003.04.010
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MA Hua-zhi , LIU Zheng-xing , WANG Quan-jun , et al
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Abstract: Purpose:To study the breaking effects of Cisplatin, Carboplatin and Dicycloplatin on pBR322 plasmid DNA. Methods:Agrose gel electrophoresis and Gel image analysis was used. Results:All three platinum-species drugs could cause DNA break of pBR322 plasmid. The FC50 of Cisplatin, Carboplatin and Dicycloplatin were 33.71 μmol/L, 3.31 mmol/L, and 1.61 mmol/L , respectively. Conclusion:Breaking effects of tested drugs: Cisplatin > Dicycloplatin > Carboplatin.
Key words: cisplatin;carboplatin;dicycloplatin;DNA break;agrose gel electrophoresis, gel image analysis
MA Hua-zhi , LIU Zheng-xing , WANG Quan-jun , et al. THE BREAKING EFFECTS OF CISPLATIN, CARBOPLATIN AND DICYCLOPLATIN ON pBR322 PLASMID DNA[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2003, 15(4): 220-222.
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