Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (4): 214-216.doi: 10.3969/j.issn.1004-616x.2004.04.008
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LIU Feng, CHEN Yuan-yu, LI Guan-wu, et al
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Abstract: BACKGROUND ＆ AIM： To learn the expression and activation of Stat1 protein in the peripheral blood white cells of acute myeloid leukemia(AML) by combing to the nuclear matrix. MATERIAL AND METHODS: The Stat1 activation were detected by western blot with anti-Stat1 antibody. RESULT:The results showed that Stat1 was activated in the 22/41(53.7 ％) with AML and 0 ％ in the 15 normal controls, and activated Stat1 existed in the nuclear matrix components. CONCLUSION: The conclusion denotes that over expression and activation of Stat1 maybe play an important role in the process of AML by attaching to nuclear matrix .
Key words: acute myeloid leukemia, Stat1 protein, nuclear matrix
LIU Feng, CHEN Yuan-yu, LI Guan-wu, et al. Activation of the Stat1 Protein in the Peripheral Blood White Cells of the Patients with Acute Myeloid Leukemia[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2004, 16(4): 214-216.
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