Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (6): 362-364.doi: 10.3969/j.issn.1004-616x.2004.06.014

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Effect on Testicular Germ Cell and Sperm in Mouse After Exposure to Hydroxylammonium Nitrate

JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al   

  1. Department of Hygienic Toxicology,Preventive Medicine College,Third Millitary Medical University,Chongqing 400038,China
  • Received:2004-06-15 Revised:2004-08-10 Online:2004-11-30 Published:2004-11-30
  • Contact: CAO Jia

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Abstract: BACKGROUND ＆ AIM: To study the reproductive damage of testicular germ cell and the deformity of sperm in mouse induced by Hydroxylammonium Nitrate(HAN). MATERIAL AND METHODS: Testicular germ cell micronucleus test,sperm deformity assay and flow cytometry were used. RESULTS: It showed that the percentage of deformity in sperm was markedly increaed as the dose increased(P<0.05), the percentage of micronucleus was significately decreased as the dose increased(P<0.05). The toxic effect of sperm was correlated with exposuring HAN . CONCLUSION: It suggested that HAN might have reproductive damage effect to testicular germ cell and sperm in mice.

Key words: hydroxylammonium nitrate(HAN), testicular germ cell micronucleus, sperm, flow cytometry